Concentration of MMP-8 and IL-1β in gingival crevicular fluid in patients with chronic and aggressive periodontitis

Małgorzata Nędzi-Góra; Renata Górska; Jolanta Kostrzewa-Janicka; Jan Kowalski

doi:10.5114/ceji.2017.72824

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2017
vol. 42

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abstract:

Clinical immunology

Concentration of MMP-8 and IL-1β in gingival crevicular fluid in patients with chronic and aggressive periodontitis

Małgorzata Nędzi-Góra

,

Renata Górska

,

Jolanta Kostrzewa-Janicka

,

Jan Kowalski

(Centr Eur J Immunol 2017; 42 (4): 342-346)

DOI: https://doi.org/10.5114/ceji.2017.72824

Online publish date: 2017/12/30

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Modern research confirms the role of inflammatory mediators in the pathomechanism of periodontal tissue destruction. The aim of the study was to determine concentrations of MMP-8 and IL-1βin gingival crevicular fluid (GCF) in patients with advanced chronic and aggressive periodontitis. The authors measured the concentrations of the above inflammatory mediators in gingival crevicular fluid of deep pockets (PD ≥ 6 mm) and shallow pockets (PD 4-5 mm) in 33 patients with advanced chronic periodontitis and in 16 patients with aggressive periodontitis. The control group consisted of 16 individuals with healthy periodontium. In all patients levels of MMP-8 and IL-1β in GCF were determined with the ELISA method. The study showed significantly higher concentrations of MMP-8 and IL-1β

in GCF of both deep and shallow pockets in patients with periodontitis compared to healthy subjects. No difference in concentrations of the tested mediators was observed with reference to diagnosis of aggressive periodontitis (AP) or chronic periodontitis (CP).

keywords:

Concentration of MMP-8 and IL-1β in gingival crevicular fluid in patients with chronic and aggressive periodontitis

Małgorzata Nędzi-Góra , Renata Górska , Jolanta Kostrzewa-Janicka , Jan Kowalski

periodontitis, markers, gingival crevicular fluid

Małgorzata Nędzi-Góra

,

Renata Górska

,

Jolanta Kostrzewa-Janicka

,

Jan Kowalski