Dexlansoprazole – a new-generation proton pump inhibitor

Barbara Skrzydło-Radomańska; Piotr Radwan

doi:10.5114/pg.2015.56109

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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4/2015
vol. 10

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abstract:

Review paper

Dexlansoprazole – a new-generation proton pump inhibitor

Barbara Skrzydło-Radomańska

,

Piotr Radwan

Prz Gastroenterol 2015; 10 (4): 191–196

DOI: https://doi.org/10.5114/pg.2015.56109

Online publish date: 2015/12/16

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Dexlansoprazole modified release (MR) is an R-enantiomer of lansoprazole and a new-generation proton pump inhibitor exhibiting high efficacy in the treatment of symptoms and lesions associated with erosive oesophagitis caused by gastroesophageal reflux disease (GERD). The dual release of the active ingredient – in the duodenum and the small intestine – makes it possible to achieve two peak concentrations at various times, within two and five hours of administration. Dexlansoprazole MR ensures the longest maintenance of drug concentration in the plasma of all known proton pump inhibitors, and the longest proton pump inhibitory effect. The basic indications for the drug include all forms of gastroesophageal reflux disease, especially with night-time heartburn and sleep disorders resulting from GERD. Dexlansoprazole can be taken regardless of meal times. It has a good safety profile and carries a low risk of adverse interactions with other drugs.

keywords:

Dexlansoprazole – a new-generation proton pump inhibitor

Barbara Skrzydło-Radomańska , Piotr Radwan

proton pump inhibitor, dexlansoprazole, R-enantiomer, treatment of gastroesophageal reflux disease

Barbara Skrzydło-Radomańska

,

Piotr Radwan