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Journal of Contemporary Brachytherapy
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Dose coverage comparison between “interstitial catheter-only” and “hybrid intracavitary-interstitial brachytherapy” for early stage squamous cell carcinoma of the buccal mucosa

Naoya Murakami, Takao Ueno, Wakako Yatsuoka, Hiroyuki Okamoto, Nikolaos Tselis, Koji Masui, Ken Yoshida, Kana Takahashi, Koji Inaba, Kae Okuma, Hiroshi Igaki, Yuko Nakayama, Jun Itami

J Contemp Brachytherapy 2018; 10, 5: 486–491
Online publish date: 2018/10/31
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When squamous cell carcinoma of the buccal mucosa (BSCC) extends surrounding anatomical sites such as gingiva, retromolar triangle, or hard palate, it might be challenging to ensure adequate tumor coverage by sole interstitial brachytherapy due to the complexity of catheter implantation. By combining interstitial catheters with an enoral placed, individually assembled “oral spacer plus embedded catheters” device (hybrid of intracavitary-interstitial brachytherapy), it should be easier to deliver the necessary tumoricidal dose to irregular-shaped tumor volumes (clinical target volume – CTV) with improved conformity. The purpose of this analysis was to compare the dose distribution created by the hybrid of intracavitary-interstitial brachytherapy (HBT) with the dose distribution of an interstitial catheter only-approach, based on the interstitial catheters used for HBT (ISBT-only) by evaluating respective treatment plans (HBT plan vs. ISBT-only plan) for the treatment of early stage BSCC.

Material and methods
A retrospective analysis was performed for patients with localized BSCC treated between April 2013 and October 2017. All patients received sole HBT without additional external beam radiation therapy or planned neck dissection. Dosimetric parameters taken into account for comparison between actual HBT and virtual ISBT-only were CTV D90, CTV V100, CTV V150, CTV V200, mandible D2cc, and mucosal surface D2cc.

Dosimetrically, HBT showed a trend toward better CTV D90 compared to ISBT-only. In addition, HBT demonstrated statistically better CTV V100 coverage compared to ISBT-only. There was no statistically significant difference with respect to CTV V150, CTV V200, and mucosal surface D2cc, while a trend was seen in better mandible D0.1cc between HBT and ISBT-only.

The HBT approach appears to enable improved dose coverage of irregular-shaped enoral tumor volumes compared to ISBT-only for patients with early stage BSCC.


brachytherapy, buccal mucosa, hybrid, interstitial brachytherapy, squamous cell carcinoma

National Comprehensive Cancer Network (NCCN). NCCN Clinical practice guidelines in oncology: Head and Neck Cancers. Version 2.2017. https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf
Huang SF, Chang JTC, Liao CT et al. The role of elective neck dissection in early stage buccal cancer. Laryngoscope 2015; 125: 128-133.
Strome SE, To W, Strawderman M et al. Squamous cell carcinoma of the buccal mucosa. Otolaryngol Head Neck Surg 1999; 120: 375-379.
Lo TC, Wiley AL, Jr., Ansfield FJ et al. Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study. AJR Am J Roentogenol 1976; 126: 229-235.
Sher DJ, Thotakura V, Balboni TA et al. Treatment of oral cavity squamous cell carcinoma with adjuvant or definitive intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 2011; 81: e215-e222.
Daly ME, Le QT, Kozak MM et al. Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control. Int J Radiat Oncol Biol Phys 2011; 80: 1412-1422.
Studer G, Brown M, Bredell M et al. Follow up after IMRT in oral cavity cancer: update. Radiat Oncol 2012; 7: 84-91.
Lapeyre M, Peiffert D, Malissard L et al. An original technique of brachytherapy in the treatment of epidermoid carcinomas of the buccal mucosa. Int J Radiat Oncol Biol Phys 1995; 33: 447-454.
Mazeron JJ, Ardiet JM, Haie-Meder C et al. GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas. Radiother Oncol 2009; 91: 150-156.
Nag S, Cano E, Demanes DJ et al. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma. Int J Radiat Oncol Biol Phys 2001; 50: 1190-1198.
Vedasoundaram P, Prasanna AK, Ks R et al. Role of high dose rate interstitial brachytherapy in early and locally advanced squamous cell carcinoma of buccal mucosa. Springerplus 2014; 3: 590-597.
Yoden E, Hiratsuka J, Imajo Y et al. High dose rate microselectron mold radiotherapy of a widespread superficial oral cancer. Int J Oral Maxillofac Surg 1999; 28: 451-453.
Bhalavat R, Chandra M, Pareek V et al. High-dose-rate brachytherapy in head and neck cancer: do we need a look back into a forgotten art – a single institute experience. J Contemp Brachytherapy 2017; 9: 124-131.
Gerbaulet A. The GEC-ESTRO handbook of brachytherapy. 11 Buccal mucosa cancer. 2002.265-273. ISBN 90-804532-6.
Shibuya H, Takeda M, Matsumoto S et al. Brachytherapy for non-metastatic squamous cell carcinoma of the buccal mucosa: an analysis of forty-five cased treated with permanent implants. Acta Oncol 1993; 32: 327-330.
Lubek JE, Dyalram D, Perera EH et al. A retrospective analysis of squamous carcinoma of the buccal mucosa: an aggressive subsite within the oral cavity. J Oral Maxillofac Surg 2013; 71: 1126-1131.
Liao CT, Wang HM, Nq SH et al. Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan. Oral Oncol 2006; 42: 800-809.
Tagliferri L, Budrukkar A, Lenkowicz J et al. ENT COBRA ONTOLOGY: the covariates classification system proposed by the Head & Neck and Skin GEC-ESTRO Working Group for interdisciplinary standardized data collection in head and neck patient cohorts treated with interventional radiotherapy (brachytherapy). J Contemp Brachytherapy 2018; 10: 260-266.
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