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Journal of Contemporary Brachytherapy
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ABS 2015
vol. 10
Original paper

Effectiveness and safety of a robot-assisted 3D personalized template in 125I seed brachytherapy of thoracoabdominal tumors

Xiaodong Ma, Zhiyong Yang, Shan Jiang, Bin Huo, Qiang Cao, Shude Chai, Haitao Wang

J Contemp Brachytherapy 2018; 10, 4: 368–379
Online publish date: 2018/08/31
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This research aims to evaluate the effectiveness and safety of a robot-assisted 3D personalized template in 125I seed brachytherapy of thoracoabdominal tumors.

Material and methods
Forty-three patients with different tumors were involved in this research between 2013 and 2015. They were all eligible to 125I seed implantation based on robot-assisted 3D personalized template. Meanwhile, 51 patients with similar tumors, which were treated with a conventional coplanar template, were involved for comparison. Follow-up was carried out after the surgery to evaluate the therapeutic efficacy, including overall survival (OS) of the patient and local control (LC) of the tumor. Complications were also summarized to evaluate the safety. Besides, statistical analysis was achieved to investigate possible factors associated with the result.

In the robot-assisted 3D personalized template-guided brachytherapy, the median target volume treated by the prescription dose (V100) was 95.3% (range, 92.4-109.8), and the median dose administered to 90% of the target volume (D90) was 126.1 Gy (range, 114.2-132.0), improved 5% and 8% compared with the conventional template-guided brachytherapy, respectively. The median OS was 30 months (95% CI: 19.4-40.6) and the rates of 2-year OS and LC were 58.1% and 86.0%, respectively. The median OS was prolonged 10 months and the 2-year OS and LC were improved 18.9% and 23.3% compared with the conventional template-guided brachytherapy, respectively.

Through analysis of the selected patients with thoracoabdominal tumors, the robot-assisted 3D personalized template in 125I seed brachytherapy was a more effective and safer method. It can achieve a more favorable OS and LC.


brachytherapy, 3D personalized template, robot-assisted, seed implantation, thoracoabdominal

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65: 5-29.
Chen W, Zheng R, Baade PD et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016; 66: 115-132.
Thorn CF, Oshiro C, Marsh S et al. Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics 2011; 21: 440-446.
Florea AM, Büsselberg D. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects. Cancers (Basel) 2011; 3: 1351-1371.
Kawalec P, Łopuch S, Mikrut A. Effectiveness of targeted therapy in patients with previously untreated metastatic breast cancer: a systematic review and meta-analysis. Clin Breast Cancer 2015; 15: 90-100.
Lim JE, Chien MW, Earle CC. Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg 2003; 237: 74-85.
Van Mierlo KM, Schaap FG, Dejong CH et al. Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure. J Hepatol 2016; 65: 1217-1231.
Jagsi R, Momoh AO, Qi J et al. Impact of Radiotherapy on Complications and Patient-Reported Outcomes After Breast Reconstruction. J Natl Cancer Inst 2018; https://doi.org/10.1093/jnci/djx148.
Yao L, Jiang Y, Jiang P et al. CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy. Brachytherapy 2015; 14: 662-669.
Li J, Zhang L, Xu W et al. Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results. J Contemp Brachytherapy 2017; 9: 132-138.
Lu M, Yao W, Zhang T et al. Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience. Oncologist 2017; 22: 1500-1505.
Sylvester J, Grimm P, Naidoo D et al. First report on the use of a thinner 125 I radioactive seed within 20-gauge needles for permanent radioactive seed prostate brachytherapy: Evaluation of postimplant dosimetry and acute toxicity. Brachytherapy 2013; 12: 375-381.
Huo X, Huo B, Wang H et al. Implantation of computed tomography-guided Iodine-125 seeds in combination with chemotherapy for the treatment of stage III non-small cell lung cancer. J Contemp Brachytherapy 2017, 9: 527-534.
Li J, Xie Q, Wang W et al. CT-guided implantation of I-125 seeds (permanent brachytherapy) for metastatic tumors of the hepatic portal system: Effectiveness and safety in 13 patients. Brachytherapy 2016; 15: 224-230.
Huo X, Huo B, Wang H et al. Percutaneous computed tomography-guided permanent 125I implantation as therapy for pulmonary metastasis. J Contemp Brachytherapy 2018; 10: 132-141.
Martinez-Monge R, Nag S, Nieroda CA et al. Iodine-125 brachytherapy in the treatment of colorectal adenocarcinoma metastatic to the liver. Cancer 2015; 85: 1218-1225.
Chai SD, Zheng GJ, Mao YQ et al. CT guided transcutaneous interstitial implantation of (125)I seeds for lung carcinoma. Chinese J Radiat Oncol 2004; 13: 291-293.
Huang MW, Liu SM, Zheng L et al. A digital model individual template and CT-guided 125I seed implants for malignant tumors of the head and neck. J Radiat Res 2012; 53: 973-977.
Ji Z, Jiang Y, Su L et al. Dosimetry Verification of (125)I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors. Technol Cancer Res Treat 2017; 16: 1044-1050.
Wang H, Wang JJ, Jiang YL et al. CT guidance 125I seed implantation for pelvic recurrent rectal cancer assisted by 3D printing individual non-coplanar template. Zhonghua Yi Xue Za Zhi 2016; 96: 3782-3786 [Article in Chinese].
Lin L, Wang J, Jiang Y et al. Interstitial 125I Seed implantation for cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous cell carcinoma. Technol Cancer Res Treat 2015; 14: 201-207.
Han T, Yang X, Xu Y et al. Therapeutic value of 3-D printing template-assisted I-125-seed implantation in the treatment of malignant liver tumors. Oncotargets Ther 2017; 10: 3277-3283.
Dou H, Jiang S, Yang Z et al. Design and validation of a CT-guided robotic system for lung cancer brachytherapy. Med Phys 2017; 44: 4828-4837.
Nath R, Anderson LL, Luxton G et al. Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPMRadiation Therapy Committee Task Group No. 43. Med Phys 1999; 26: 2514-2520.
Rivard MJ, Coursey BM, DeWerd LA et al. Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations. Med Phys 2004; 31: 633-674.
Yang B, Sun X, Pang H et al. Dosimetric analysis of rib interference of the CTV during interstitial brachytherapy of lung tumors. J Contemp Brachytherapy 2017; 9: 566-571.
Feuvret L, Noël G, Mazeron JJ et al. Conformity index: A review. Int J Radiat Oncol Biol Phys 2006; 64: 333-342.
Kataria T, Sharma K, Subramani V et al. Homogeneity Index: An objective tool for assessment of conformal radiation treatments. J Med Phys 2012; 37: 207-213.
Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis 2010; 30: 52-60.
Wang Z, Liu Y, Liu F et al. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. Eur Radiol 2010; 20: 1786-1791.
Liu K, Ji B, Zhang W et al. Comparison of Iodine-125 Seed Implantation and Pancreaticoduodenectomy in the Treatment of Pancreatic Cancer. Int J Med Sci 2014; 11: 893-896.
Shi L, Wu C, Wu J et al. Computed tomography-guided permanent brachytherapy for locoregional recurrent gastric cancer. Radiat Oncol 2012; 7: 114-123.
Huo XD, Wang HX, Yang JK et al. Effectiveness and safety of CT-guided 125I seed brachytherapy for postoperative locoregional recurrence in patients with nonesmall cell lung cancer. Brachytherapy 2016; 15: 370-380.
Zhang L, Chen L, Wang J et al. CT-guided radioactive I-125 seed implantation treatment of multiple pulmonary metastases of hepatocellular carcinoma. Clin Radiol 2014; 69: 624-629.
Wang JJ, Yuan HS, Li JN et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy. Med Oncol 2010; 27: 421-429.
Karam SD, Horne ZD, Hong RL et al. Dose escalation with stereotactic body radiation therapy boost for locally advanced non small cell lung cancer. Radiat Oncol 2013; 8: 179.
Lu M, Pu D, Zhang W et al. Trans-bronchoscopy with implantation of I-125 radioactive seeds in patients with pulmonary atelectasis induced by lung cancer. Oncol Lett 2015; 10: 216-222.
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