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Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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Original paper

Effects of azithromycin on lung oxidative injury and immune function in mice infected with Mycoplasma pneumoniae based on the Nrf2/ARE signaling pathway

Qiuhua Chen
1
,
Manzhou Lin
1
,
Huamin Zhang
1
,
Donglan Chen
1

  1. Guangdong Medical University Affiliated Hospital, Guangdong, China
Cent Eur J Immunol 2025; 50 (3)
Online publish date: 2025/06/12
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1. Goycochea-Valdivia WA, Ares Alvarez J, Conejo Fernan- dez AJ, et al. (2024): Position statement of the Spanish Society of Paediatric Infectious diseases on the diagnosis and treatment of Mycoplasma pneumoniae infection. An Pediatr (Engl Ed) 101: 46-57.
2. Kenri T (2023): Genetic manipulation of Mycoplasma pneumoniae. Methods Mol Biol 2646: 347-357.
3. Goeijenbier M, van der Bie S, Souverein D, et al. (2024): Post COVID-19 pandemic increased detection of Mycoplasma pneumoniae in adults admitted to the intensive care. J Clin Med 13: 3443.
4. Peng Y, Chen Z, Li Y, et al. (2022): Combined therapy of Xiaoer Feire Kechuan oral liquid and azithromycin for mycoplasma Pneumoniae pneumonia in children: a systematic review and meta-analysis. Phytomedicine 96: 153899.
5. Tsai TA, Tsai CK, Kuo KC, Yu HR (2021): Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children. J Microbiol Immunol Infect 54: 557-565.
6. Sandman Z, Iqbal OA. Azithromycin. StatPearls Publishing, Treasure Island (FL) 2025.
7. Heidary M, Ebrahimi Samangani A, Kargari A, et al. (2022): Mechanism of action, resistance, synergism, and clinical implications of azithromycin. J Clin Lab Anal 36: e24427.
8. 8. Parnham MJ, Erakovic Haber V, Giamarellos-Bourboulis EJ, et al. (2014): Azithromycin: mechanisms of action and their relevance for clinical applications. Pharmacol Ther 143: 225-245.
9. Chen M, Yang T, Meng X, Sun T (2015): Azithromycin attenuates cigarette smoke extract-induced oxidative stress injury in human alveolar epithelial cells. Mol Med Rep 11: 3414-3422.
10. Tang F, Li R, Xue J et al. (2017): Azithromycin attenuates acute radiation-induced lung injury in mice. Oncol Lett 14: 5211-5220.
11. Hassanein EHM, Sayed GA, Alzoghaibi AM, et al. (2022): Azithromycin mitigates cisplatin-induced lung oxidative stress, inflammation and necroptosis by upregulating SIRT1, PPARgamma, and Nrf2/HO-1 signaling. Pharmaceuticals (Basel) 16: 52.
12. Birrell JM, Woolnough E, Spencer E (2019): Mycoplasma pneumoniae with para-infectious cerebral complications. Respir Med Case Rep 27: 100859.
13. Dian D, Zhang W, Lu M, et al. (2023): Clinical efficacy of ulinastatin combined with azithromycin in the treatment of severe pneumonia in children and the effects on inflammatory cytokines and oxidative stress: a retrospective cohort study. Infect Drug Resist 16: 7165-7174.
14. Chen Y, Dong S, Tian L, et al. (2022): Combination of azithromycin and methylprednisolone alleviates Mycoplasma pneumoniae induced pneumonia by regulating miR-499a-5p/STAT3 axis. Exp Ther Med 24: 578.
15. Buendia I, Michalska P, Navarro E et al. (2016): Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157: 84-104.
16. Liang M, Meng Y, Wang X, et al. (2022): The effectiveness of wogonin on treating cough mice with Mycoplasma pneumoniae infection. Front Mol Biosci 9: 803842.
17. 17. Shi S, Zhang X, Zhou Y, et al. (2019): Immunosuppression reduces lung injury caused by Mycoplasma pneumoniae infection. Sci Rep 9: 7147.
18. Liu X, Wang M, Kan Q, et al. (2022): Qingfei Tongluo formula mitigates Mycoplasma pneumoniae infection via the PERK signaling pathway. Dis Markers 2022: 9340353.
19. Ma C, Gu C, Lian P, et al. (2023): Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. Cell Death Dis 14: 768.
20. Ding N, Lei A, Shi Z, et al. (2023): Total flavonoids from camellia oleifera alleviated Mycoplasma pneumoniae-induced lung injury via inhibition of the TLR2-mediated NF-kappaB and MAPK pathways. Molecules 28: 7077.
21. Wei W, Wan H, Peng X, et al. (2018): Antiviral effects of Ma Huang Tang against H1N1 influenza virus infection in vitro and in an ICR pneumonia mouse model. Biomed Pharmacother 102: 1161-1175.
22. Qian J, Xue M (2022): Pinocembrin relieves Mycoplasma pneumoniae infection induced pneumonia in mice through the inhibition of oxidative stress and inflammatory response. Appl Biochem Biotechnol 194: 6335-6348.
23. Kang JY, Xu MM, Sun Y, et al. (2022): Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis. Int Immunopharmacol 109: 108782.
24. 24. Hu J, Ye Y, Chen X, et al. (2022): Insight into the pathogenic mechanism of Mycoplasma pneumoniae. Curr Microbiol 80: 14.
25. Xue Y, Wang M, Han H (2023): Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection. Front Cell Infect Microbiol 13: 1052020.
26. Oliver ME, Hinks TSC (2021): Azithromycin in viral infections. Rev Med Virol 31: e2163.
27. Jain S, Durugkar S, Saha P, et al. (2022): Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation. Eur J Pharmacol 915: 174467.
28. Ansari AW, Sharif-Askari FS, Jayakumar MN, et al. (2020): Azithromycin differentially alters TCR-activated helper T cell subset phenotype and effector function. Front Immunol 11: 556579.
29. BioMed Research International (2023): Retracted: Kukoamine A improves Mycoplasma pneumoniae pneumonia by regulating miR-222-3p/superoxide dismutase 2. Biomed Res Int 2023: 9786745.
30. Lana JV, Rios A, Takeyama R, et al. (2024): Nebulized glutathione as a key antioxidant for the treatment of oxidative stress in neurodegenerative conditions. Nutrients 16: 2476.
31. Song Y, Fu W, Zhang Y, et al. (2023): Azithromycin ameliorated cigarette smoke-induced airway epithelial barrier dysfunction by activating Nrf2/GCL/GSH signaling pathway. Respir Res 24: 69.
Copyright: © 2025 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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