eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2015
vol. 40
 
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abstract:
Clinical immunology

Elevated expression of interleukin-21 and its correlation to T-cell subpopulation in patients with ulcerative colitis

Jian Ge
,
Xiaohua Zhang
,
Jin Liu
,
Zhenmei Fu
,
Xiuju Shi
,
Qingyan Li
,
Jiyong Liu
,
Qiang Zhu

(Cent Eur J Immunol 2015; 40 (3): 331-336)
DOI: https://doi.org/10.5114/ceji.2015.54595
Online publish date: 2015/10/15
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Objective: To investigate the expression of interleukin-21 (IL-21) and its correlation to T-cell subpopulation including Th1, Tc1 and Th17 cells in Ulcerative colitis (UC).

Material and methods: We examined the expression of IL-21, IL-17 and IFN-γin UC patients and controls by enzyme-linked immunosorbent assay (ELISA) and flow cytometry.

Results: We found that IL-21 was expressed on CD3+CD8-T cells by flow cytometry. Plasma IL-21 level and the percentage of CD3+CD8-IL-21+ T cells were significantly elevated in UC patients compared to controls. The percentage of CD3+CD8-IL-17+ T (Th17), CD3+CD8-IFN-γ+ T (Th1) and CD3+CD8+IFN-γ+ T (Tc1) cells was also significantly increased in UC patients. Moreover, we found a significant positive correlation between CD3+CD8-IL-21+T cells and Th17 cells.

Conclusions: Elevated IL-21 and its positive correlation to Th17 cells may play a role in the pathogenesis of UC.
keywords:

ulcerative colitis, interleukin-21, T helper 1, T helper 17

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