Endometrial carcinoma – hormonal relations

Wojciech Kaźmierczak

ISSN: 1231-6407

Ginekologia Praktyczna - - - ARCHIVAL

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2/2004
vol. 12

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abstract:

Endometrial carcinoma – hormonal relations

Wojciech Kaźmierczak

Ginek Prakt 2004, 12, 2, 13-16

Online publish date: 2004/05/20

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Endometrial carcinoma is the fifth most common female malignancy. Those who are postmenopausal and live in a western world are at highest risk. Increased ratio of estrogens against progestogens is regarded as a potential risk factor as is having a history of an androgenic phenotype.
Hyperstimulation of the endometrial androgenic receptor is responsible for decreased proliferation indices within this epithelium. However, it is a secondary hyperestrogenism not opposed by progestogens that is blamed to raise the risk. Better understanding of this mechanism is likely to improve diagnosis and management of endometrial malignancy.

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Endometrial carcinoma – hormonal relations

Wojciech Kaźmierczak

Endometrial carcinoma, hyperestrogenism, hormone receptors, aromatase cytochrome p450