Endoscopic parathyroidectomy versus open parathyroidectomy for patients with refractory secondary hyperparathyroidism: a meta-analysis

Wei Xu; Guoyuan Lu; Lifeng Gong; Weigang Tang; Jingkui Lu

doi:10.5114/wiitm.2023.132439

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

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4/2023
vol. 18

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General surgery

abstract:

Meta-analysis

Endoscopic parathyroidectomy versus open parathyroidectomy for patients with refractory secondary hyperparathyroidism: a meta-analysis

Wei Xu

^{1, 2}

,

Guoyuan Lu

³

,

Lifeng Gong

^{1, 2}

,

Weigang Tang

^{1, 2}

,

Jingkui Lu

^{1, 2}

Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China
Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China
Department of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

Videosurgery Miniinv 2023; 18 (4): 578–587

DOI: https://doi.org/10.5114/wiitm.2023.132439

Online publish date: 2023/10/27

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Introduction
Endoscopic parathyroidectomy(EPTX) has been gradually introduced as a minimally invasive treatment for refractory secondary hyperparathyroidism (SHPT). However, it is uncertain about the efficacy and safety compared between EPTX and open parathyroidectomy (OPTX) for refractory SHPT.

Aim
This meta-analysis was conducted to evaluate the efficacy and safety of EPTX and OPTX for secondary hyperp arathyroidism (SHPT).

Material and methods
Databases including PubMed, EMbase, Cochrane Library, CNKI, and Wanfang were searched. Eligible studies comparing EPTX and OPTX for refractory SHPT were included.

Results
Compared with OPTX, EPTX has the shorter hospital stay (p < 0.01) and lower incidences of hoarseness or recurrent laryngeal nerve injury (p = 0.04). There was no significant difference between EPTX and OPTX concerning operation time (p = 0.49), intraoperative blood loss (p = 0.24), postoperative parathyroid hormone levels (p = 0.22), postoperative calcium levels (p = 0.93), postoperative phosphorus levels (p = 0.37), and complications including neck ecchymosis (p = 0.87), subcutaneous haematoma (p = 0.18), and wound infection (p = 0.11).

Conclusions
EPTX and OPTX are both effective methods for refractory SHPT. EPTX had the shorter hospital stay and lower incidences of hoarseness or recurrent laryngeal nerve injury.

keywords:

Endoscopic parathyroidectomy versus open parathyroidectomy for patients with refractory secondary hyperparathyroidism: a meta-analysis

Wei Xu 1, 2 , Guoyuan Lu 3 , Lifeng Gong 1, 2 , Weigang Tang 1, 2 , Jingkui Lu 1, 2

secondary hyperparathyroidism, meta-analysis, open parathyroidectomy, endoscopic parathyroidectomy

Wei Xu

^{1, 2}

,

Guoyuan Lu

³

,

Lifeng Gong

^{1, 2}

,

Weigang Tang

^{1, 2}

,

Jingkui Lu

^{1, 2}