Epidemiological Patterns in Tumor Transformation of Nevus
Sebaceous: a Systematic Review

Fabiola Silva; Marina Burlá; Beatriz Mendes; Yuri Siqueira; Lilia de Oliveira

doi:10.5114/dr.2025.155987

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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Otwarty dostęp

4/2025
vol. 112

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Artykuł przeglądowy

Epidemiological Patterns in Tumor Transformation of Nevus Sebaceous: a Systematic Review

Fabiola L. Silva

¹

,

Marina M. Burlá

²

,

Beatriz X. Mendes

³

,

Yuri S. Siqueira

⁴

,

Lilia Maria L. de Oliveira

⁵

Division of Dermatology, Department of Medicine, Federal University of Bahia, Brazil
Department of Medicine, Estácio de Sá Vista Carioca University, Rio de Janeiro, Brazil
Department of Medicine, Unichristus University Center, Ceara, Brazil
Department of Medicine, Universidade do Extremo Sul Catarinense, Criciuma, Brazil
Harvard T.H. Chan School of Public Health, Boston, US

Dermatol Rev/Przegl Dermatol 2025, 112, 243–248

DOI: https://doi.org/10.5114/dr.2025.155987

Data publikacji online: 2025/10/30

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Metryki PlumX:

Nevus sebaceous is a congenital hamartoma with potential for secondary tumor development. This systematic review, registered in PROSPERO (CRD42024533102), presents the largest epidemiologic analysis to date, encompassing 7,092 nevus sebaceous cases across 27 observational studies. Secondary tumors were identified in 12% of cases – 10% benign and 2% malignant. Syringocystadenoma papilliferum and trichoblastoma were the most frequent benign neoplasms, while basal cell carcinoma accounted for the majority of malignancies. Multiple neoplasms within a single lesion were rare (1%), and tumor development was more common in adult males. While benign tumors are relatively common, malignant transformation remains rare. These findings challenge the practice of routine prophylactic excision, particularly in pediatric patients, and support a more individualized approach based on clinical risk assessment and lesion characteristics.

Indeks osobowy

Epidemiological Patterns in Tumor Transformation of Nevus Sebaceous: a Systematic Review

Fabiola L. Silva 1 , Marina M. Burlá 2 , Beatriz X. Mendes 3 , Yuri S. Siqueira 4 , Lilia Maria L. de Oliveira 5

Fabiola L. Silva

¹

,

Marina M. Burlá

²

,

Beatriz X. Mendes

³

,

Yuri S. Siqueira

⁴

,

Lilia Maria L. de Oliveira

⁵