eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2015
vol. 40
 
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abstract:

Experimental immunology
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

Xiaoqian Wang
,
He Xiao
,
Yinxiang Wei
,
Xiaoling Liu
,
Gencheng Han
,
Guojiang Chen
,
Chunmei Hou
,
Beifen Shen
,
Yan Li
,
Renxi Wang

(Centr Eur J Immunol 2015; 40 (2):142-148)
Online publish date: 2015/08/03
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B-cell activating factor (BAFF) is regarded as a new therapeutic target in autoimmune diseases such as systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Along with other researchers, we have demonstrated that BAFF inhibitor atacicept (TACI-IgG) suppresses lupus and experimental allergic encephalomyelitis (EAE) by reducing the mature B-cell number but not memory B cells. It is however unclear whether TACI-Ig affects pathogenic T cells and memory T cells. In the present study, we found that blocking BAFF with TACI-IgG effectively reduces the pathogenic Th1 and Th17 cells in EAE mice. However, TACI-IgG did not reduce memory CD62L+CD44hiCD4+ and CD62L+CD44hiCD8+ T cells in EAE mice. When interleukin (IL)-15 was neutralized, memory CD62L+CD44hi T cells were significantly reduced in TACI-IgG-treated EAE mice. These results suggest that TACI-IgG is effective in effective controlling Th1 and Th17 cells, but it also increases IL-15 to upregulate memory T cells in EAE mice. The study provides hints for the clinical application of the combination of BAFF- and IL-15-specific therapeutic agents.
keywords:

TACI-IgG, EAE, BAFF, Th1, Th17, IL-15

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