Experimental immunology<br>Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

Xiaoqian Wang; He Xiao; Yinxiang Wei; Xiaoling Liu; Gencheng Han; Guojiang Chen; Chunmei Hou; Beifen Shen; Yan Li; Renxi Wang

doi:10.5114/ceji.2015.52826

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Experimental immunology
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

Xiaoqian Wang

,

He Xiao

,

Yinxiang Wei

,

Xiaoling Liu

,

Gencheng Han

,

Guojiang Chen

,

Chunmei Hou

,

Beifen Shen

,

Yan Li

,

Renxi Wang

(Centr Eur J Immunol 2015; 40 (2):142-148)

DOI: https://doi.org/10.5114/ceji.2015.52826

Online publish date: 2015/08/03

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AMA

Wang X, Xiao H, Wei Y, et al. Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. Central European Journal of Immunology. 2015;40(2):142-148. doi:10.5114/ceji.2015.52826.

APA

Wang, X., Xiao, H., Wei, Y., Liu, X., Han, G.,  & Chen, G. et al. (2015). Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. Central European Journal of Immunology, 40(2), 142-148. https://doi.org/10.5114/ceji.2015.52826

Chicago

Wang, Xiaoqian, He Xiao, Yinxiang Wei, Xiaoling Liu, Gencheng Han, Guojiang Chen,  and Chunmei Hou et al. 2015. "Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice". Central European Journal of Immunology 40 (2): 142-148. doi:10.5114/ceji.2015.52826.

Harvard

Wang, X., Xiao, H., Wei, Y., Liu, X., Han, G., Chen, G., Hou, C., Shen, B., Li, Y.,  and Wang, R. (2015). Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. Central European Journal of Immunology, 40(2), pp.142-148. https://doi.org/10.5114/ceji.2015.52826

MLA

Wang, Xiaoqian et al. "Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice." Central European Journal of Immunology, vol. 40, no. 2, 2015, pp. 142-148. doi:10.5114/ceji.2015.52826.

Vancouver

Wang X, Xiao H, Wei Y, Liu X, Han G, Chen G et al. Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. Central European Journal of Immunology. 2015;40(2):142-148. doi:10.5114/ceji.2015.52826.

PlumX metrics:

B-cell activating factor (BAFF) is regarded as a new therapeutic target in autoimmune diseases such as systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Along with other researchers, we have demonstrated that BAFF inhibitor atacicept (TACI-IgG) suppresses lupus and experimental allergic encephalomyelitis (EAE) by reducing the mature B-cell number but not memory B cells. It is however unclear whether TACI-Ig affects pathogenic T cells and memory T cells. In the present study, we found that blocking BAFF with TACI-IgG effectively reduces the pathogenic Th1 and Th17 cells in EAE mice. However, TACI-IgG did not reduce memory CD62L+CD44hiCD4+ and CD62L+CD44hiCD8+ T cells in EAE mice. When interleukin (IL)-15 was neutralized, memory CD62L+CD44hi T cells were significantly reduced in TACI-IgG-treated EAE mice. These results suggest that TACI-IgG is effective in effective controlling Th1 and Th17 cells, but it also increases IL-15 to upregulate memory T cells in EAE mice. The study provides hints for the clinical application of the combination of BAFF- and IL-15-specific therapeutic agents.

keywords:

Experimental immunologyBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

Xiaoqian Wang , He Xiao , Yinxiang Wei , Xiaoling Liu , Gencheng Han , Guojiang Chen , Chunmei Hou , Beifen Shen , Yan Li , Renxi Wang

TACI-IgG, EAE, BAFF, Th1, Th17, IL-15

Experimental immunology
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

Xiaoqian Wang

,

He Xiao

,

Yinxiang Wei

,

Xiaoling Liu

,

Gencheng Han

,

Guojiang Chen

,

Chunmei Hou

,

Beifen Shen

,

Yan Li

,

Renxi Wang