eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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SCImago Journal & Country Rank
4/2012
vol. 37
 
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abstract:

Experimental immunology
Determination of mRNA three Toll-like receptors in human carcinoma cell lines

Bartosz Brzezicha
,
Joanna Budna
,
Magdalena Frydrychowicz
,
Agata Kolecka
,
Iwona Mozer-Lisewska
,
Jan Sikora
,
Jan Żeromski

(Centr Eur J Immunol 2012; 37 (4): 318-320)
Online publish date: 2013/02/10
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Toll-like receptors (TLRs) are now considered to be active players in tumor-host interactions. Toll-like receptor protein expression on/in cancer cell depends apparently on the level of RNA transcription. Based on previous work showing presence of TLR mRNA in six carcinoma cell lines, it was attempted to determine quantitatively mRNA of TLR-2, TLR-3 and TLR-4 by rt PCR. It has been shown that the expression of mRNA of three TLRs tested was uneven among examined cell lines. These data imply that in any future anti-tumor immunotherapeutic trials involving TLRs it seems mandatory to determine precisely TLR mRNA of cancer cells.
keywords:

Toll-like receptors, quantitative rt PCR, mRNA, human cancer cell lines

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