eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
2/2013
vol. 38
 
Share:
Share:
more
 
 
abstract:

Experimental immunology
The association of single nucleotide polymorphisms in TNFAIP3 with rheumatoid arthritis in the Chinese Population

Xingang Zhang
,
Wei Li
,
Xinpeng Zhang
,
Xiaoli Zhang
,
Li Jiang
,
Yun Guo
,
Jin Zhang
,
Xiaofei Wang
,
Zaifu Liang

(Centr Eur J Immunol 2013; 38 (2): 214-220)
Online publish date: 2013/07/08
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Objective: Genome-wide association studies of rheumatoid arthritis (RA) in Caucasian populations have identified polymorphisms in and near the tumor necrosis factor α (TNF-α)-induced protein 3 gene (TNFAIP3). This study aimed to investigate the association between the critical polymorphisms in the TNFAIP3 gene and the risk of RA in the Chinese population.

Material and methods: A hospital-based case-control study of 344 RA patients and 344 matched controls was conducted. After informed consent was obtained, each person donated 2 ml of blood for biomarker testing. Three polymorphisms were determined by the TaqMan SNP genotyping method. The statistical analyses were performed primarily with SPSS (v13.0).

Results: This study showed that individuals with the rs2230926 TG genotype had an increased risk of RA compared with those carrying the TT genotype (OR = 1.74, 95% CI: 1.12-2.72, p = 0.015) and the combined TG/GG genotypes were also associated with an increased risk of RA (OR = 1.75, 95% CI:

1.13-2.72, p = 0.012). Individuals carrying the rs10499194 CT heterozygous genotype had a 1.88-fold increased risk of RA compared with those with the homozygous wild genotype CC (95% CI: 1.05-3.36,

p = 0.034). Subset analysis stratified to gender showed that significant associations were present in the female population, but not in the male population. Haplotype analysis showed that the T-A-C and G-G-C haplotypes were associated with increased risks of RA (ORs were 2.46 and 2.27, 95% CIs were 1.36-4.48 and 1.35-3.80, p values were 0.002 and 0.002, respectively).

Conclusions: The rs10499194 and rs2230926 polymorphisms in the TNFAIP3 gene region may be genetic risk modifiers for RA in the Chinese population.
keywords:

TNFAIP3 gene, single nucleotide polymorphism, rheumatoid arthritis

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.