eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 38

Experimental immunology
The association of single nucleotide polymorphisms in TNFAIP3 with rheumatoid arthritis in the Chinese Population

Xingang Zhang
Wei Li
Xinpeng Zhang
Xiaoli Zhang
Li Jiang
Yun Guo
Jin Zhang
Xiaofei Wang
Zaifu Liang

(Centr Eur J Immunol 2013; 38 (2): 214-220)
Online publish date: 2013/07/08
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Objective: Genome-wide association studies of rheumatoid arthritis (RA) in Caucasian populations have identified polymorphisms in and near the tumor necrosis factor α (TNF-α)-induced protein 3 gene (TNFAIP3). This study aimed to investigate the association between the critical polymorphisms in the TNFAIP3 gene and the risk of RA in the Chinese population.

Material and methods: A hospital-based case-control study of 344 RA patients and 344 matched controls was conducted. After informed consent was obtained, each person donated 2 ml of blood for biomarker testing. Three polymorphisms were determined by the TaqMan SNP genotyping method. The statistical analyses were performed primarily with SPSS (v13.0).

Results: This study showed that individuals with the rs2230926 TG genotype had an increased risk of RA compared with those carrying the TT genotype (OR = 1.74, 95% CI: 1.12-2.72, p = 0.015) and the combined TG/GG genotypes were also associated with an increased risk of RA (OR = 1.75, 95% CI:

1.13-2.72, p = 0.012). Individuals carrying the rs10499194 CT heterozygous genotype had a 1.88-fold increased risk of RA compared with those with the homozygous wild genotype CC (95% CI: 1.05-3.36,

p = 0.034). Subset analysis stratified to gender showed that significant associations were present in the female population, but not in the male population. Haplotype analysis showed that the T-A-C and G-G-C haplotypes were associated with increased risks of RA (ORs were 2.46 and 2.27, 95% CIs were 1.36-4.48 and 1.35-3.80, p values were 0.002 and 0.002, respectively).

Conclusions: The rs10499194 and rs2230926 polymorphisms in the TNFAIP3 gene region may be genetic risk modifiers for RA in the Chinese population.

TNFAIP3 gene, single nucleotide polymorphism, rheumatoid arthritis

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