Experimental immunology<br>The impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine

Tarik Purtuloglu; Gokhan Aydemir; Mehmet Saldir; Abdulbaki Karaoglu; Galip Erdem; Kursat M. Fidanci; Oguzhan Babacan; Ferhat Cekmez; Turan Tunc; Halil Yaman; Serdar Umit Sarici

doi:10.5114/ceji.2012.32715

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2012
vol. 37

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abstract:

Experimental immunology
The impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine

Tarik Purtuloglu

,

Gokhan Aydemir

,

Mehmet Saldir

,

Abdulbaki Karaoglu

,

Galip Erdem

,

Kursat M. Fidanci

,

Oguzhan Babacan

,

Ferhat Cekmez

,

Turan Tunc

,

Halil Yaman

,

Serdar Umit Sarici

(Centr Eur J Immunol 2012; 37 (4): 303-306)

DOI: https://doi.org/10.5114/ceji.2012.32715

Online publish date: 2013/02/10

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Background: The gastrointestinal system constitutes an important part of immune system in newborns. Toll-like receptors (TLRs) are pattern recognition molecules that initiate innate immune responses in newborn gut. The aim of the study was to investigate the responsiveness of intestinal Toll-like receptors 2 (TLR-2), TLR-4 and TLR-9 levels to postnatal steroid therapy.

Material and methods: Rats were randomly assigned to three experimental groups. Group I (control at day 0) (n = 9), group II (control at day 10) (n = 9): oral distilled water, group III (study group) (n = 9): oral dexamethasone (0.5 mg/kg/day). After 10 days, the ileojejunal segment was removed for biochemical analyses of TLR-2, TLR-4 and TLR-9.

Results: There was no statistically significant difference between groups for TLR-2 and TLR-4 levels. There was a significant difference between groups for TLR-9 levels. There were no significant difference between group I and III and both groups were significantly higher than group II for TLR-9 levels.

Conclusions: Postnatal steroid treatment may reduce TLR-4 level via increasing the level of TLR-9. Thus, it may lead to limited beneficial and protective effect against necrotizing enterocolitis which is a deleterious disease of the newborn gastrointestinal tract.

keywords:

Experimental immunologyThe impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine

Tarik Purtuloglu , Gokhan Aydemir , Mehmet Saldir , Abdulbaki Karaoglu , Galip Erdem , Kursat M. Fidanci , Oguzhan Babacan , Ferhat Cekmez , Turan Tunc , Halil Yaman , Serdar Umit Sarici

Toll-like receptor, dexamethasone, newborn, intestine

Experimental immunology
The impact of oral dexamethasone on Toll-like receptor levels in neonatal rat intestine

Tarik Purtuloglu

,

Gokhan Aydemir

,

Mehmet Saldir

,

Abdulbaki Karaoglu

,

Galip Erdem

,

Kursat M. Fidanci

,

Oguzhan Babacan

,

Ferhat Cekmez

,

Turan Tunc

,

Halil Yaman

,

Serdar Umit Sarici