eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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5/2018
vol. 10
 
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abstract:
Original paper

Experimental study of pelvic perioperative brachytherapy with iodine 125 seeds (I-125) in an animal model

Thomas Brun, Gwenael Ferron, Thomas Filleron, Jacques Bonnet, Alejandra Martinez, Anne Ducassou, Fabien Corbiere, Martine Delannes

J Contemp Brachytherapy 2018; 10, 5: 463–469
Online publish date: 2018/10/31
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Purpose
The aim of this study is to investigate the feasibility of perioperative I-125 low-dose-rate brachytherapy mesh implantation in pelvic locations in an animal model, before applying it clinically.

Material and methods
The animal model was the Romanov adult ewe. Non-radioactive dummy I-125 seeds were implanted by laparotomy in the pelvic area. Forty-five dummy seeds were placed on a 10 cm² polyglactin mesh to obtain a dose of 160 Gy at 5 mm from the center of each seed. Three CT scans were performed at day 15, day 70, and day 180 after surgery to check the positioning of the mesh for eventual seed migration according to bony landmarks and to perform a 3D theoretical dosimetric study. The experimental study design was based on Simon’s minimax plan with a preliminary analysis of 10 ewes to validate the protocol and a second series of 7 ewes.

Results
After the first step, 9 of 10 ewes were investigated. For 8 of 9 animals, the 160 Gy isodose line volume was within 10%, showing feasibility of the procedure and allowing 7 more to be added. At the end of the study, 16 of 17 animals were examined. No seeds loss was observed. The volume difference of the 160 Gy isodose line was within 10% in 13 of 16 ewes between the three CT scans. Twelve out of 16 had a coordinate deviation less than or equal to 10 mm on the three axes between the first and the third scans.

Conclusions
These results show the technical feasibility of the pelvic mesh implantation in ewes. A phase I study for patients with locally advanced or recurrent pelvic tumors amenable to surgery, in combination with surgical resection should be possible.

keywords:

I-125 seeds, animal model, brachytherapy, pelvic location

 
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