Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation

Yöntem Yaman; Gökhan Baysoy; Emre Keleşoğlu; Kürşat Özdilli; Aslı Çakır; Dildar Bahar Genç; Murat Elli; Sema Anak

doi:10.5114/wo.2019.83815

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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1/2019
vol. 23

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abstract:

Case report

Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation

Yöntem Yaman

¹

,

Gökhan Baysoy

²

,

Emre Keleşoğlu

³

,

Kürşat Özdilli

¹

,

Aslı Çakır

⁴

,

Dildar Bahar Genç

⁵

,

Murat Elli

¹

,

Sema Anak

¹

Department of Pediatric Hematology and Oncology, Faculty of Medicine, Medipol University, Istanbul, Turkey

Department of Pediatric Gastroenterology, Medical Faculty, Medipol University, Istanbul, Turkey

Department of Pediatrics, Medical Faculty, Medipol University, Istanbul, Turkey

Department of Pathology, Medical Faculty, Medipol University, Istanbul, Turkey

Department of Pediatric Hematology and Oncology, Şişli Etfal Hamidiye Training and Research Hospital, Istanbul, Turkey

Contemp Oncol (Pozn) 2019; 23 (1): 59-62

DOI: https://doi.org/10.5114/wo.2019.83815

Online publish date: 2019/03/25

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In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT.

keywords:

Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation

Yöntem Yaman 1 , Gökhan Baysoy 2 , Emre Keleşoğlu 3 , Kürşat Özdilli 1 , Aslı Çakır 4 , Dildar Bahar Genç 5 , Murat Elli 1 , Sema Anak 1

graft-versus-host disease, child, neuroblastoma, autologous stem cell transplantation

Yöntem Yaman

¹

,

Gökhan Baysoy

²

,

Emre Keleşoğlu

³

,

Kürşat Özdilli

¹

,

Aslı Çakır

⁴

,

Dildar Bahar Genç

⁵

,

Murat Elli

¹

,

Sema Anak

¹