eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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Open access

without publication fees
2/2015
vol. 10
 
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abstract:
Review paper

Haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection

Yuan Li
,
Xuefeng Xia
,
Jing Zhang
,
Zhiqiang Song
,
Liya Zhou
,
Yaopeng Zhang
,
Yonghui Huang
,
Yanyan Shi
,
Eamonn M.M. Quigley
,
Shigang Ding

Prz Gastroenterol 2015; 10 (2): 78–82
DOI: https://doi.org/10.5114/pg.2015.48995
Online publish date: 2015/02/10
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Patients with inflammatory bowel disease (IBD) are at risk of developing haemophagocytic lymphohistiocytosis (HLH) because of chronic systemic inflammation as well as exposure to immunosuppressive medications. The two main causes of HLH in IBD patients are infection with cytomegalovirus and Epstein-Barr virus. Patients with Crohn’s disease are more susceptible to HLH than those with ulcerative colitis. The majority of cases are seen in people receiving an immunosuppressive regimen that included thiopurines.
keywords:

haemophagocytic lymphohistiocytosis, inflammatory bowel disease, cytomegalovirus, Epstein-Barr virus, thiopurines
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