Przegląd Gastroenterologiczny

Health benefits of oat dietary fibre in inflammatory bowel disease: a systematic review

  1. Faculty of Medicine and Life Sciences, University of Latvia, Latvia
Gastroenterology Rev
Data publikacji online: 2026/05/27
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  1. Serrano-Gómez G, Mayorga L, Oyarzun I, et al. Dysbiosis and relapse-related microbiome in inflammatory bowel disease: a shotgun metagenomic approach. Comput Struct Biotechnol J 2021; 19: 6481-9.
  2. Loy L, Petronio L, Marcozzi G, et al. Dietary fiber in inflammatory bowel disease: are we ready to change the paradigm? Nutrients 2024; 16: 1108.
  3. Di Rosa C, Altomare A, Imperia E, et al. The role of dietary fibers in the management of IBD symptoms. Nutrients 2022; 14: 4775.
  4. Shin Y, Han S, Kwon J, et al. Roles of short-chain fatty acids in inflammatory bowel disease. Nutrients 2023; 15: 4466.
  5. Larraufie P, Martin-Gallausiaux C, Lapaque N, et al. SCFAs strongly stimulate PYY production in human enteroendocrine cells. Sci Rep 2018; 8: 74.
  6. Venegas DP, De La Fuente MK, Landskron G, et al. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol 2019; 10: 277.
  7. Ventura I, Chomon-García M, Tomás-Aguirre F, et al. Therapeutic and immunologic effects of short-chain fatty acids in inflammatory bowel disease: a systematic review. Int J Mol Sci 2024; 25: 10879.
  8. Vidyasagar S, Barmeyer C, Geibel J, et al. Role of short-chain fatty acids in colonic HCO3 secretion. Am J Physiol Gastrointest Liver Physiol 2005; 288: G1217-26.
  9. Becker HM, Seidler UE. Bicarbonate secretion and acid/base sensing by the intestine. Pflugers Arch Eur J Physiol 2024; 476: 593-610.
  10. McCoubrey LE, Seegobin N, Sangfuang N, et al. The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome. J Control Release 2024; 369: 630-41.
  11. Zhang Z, Zhang H, Chen T, et al. Regulatory role of short-chain fatty acids in inflammatory bowel disease. Cell Commun Signal 2022; 20: 64.
  12. Xu M, Ling F, Li J, et al. Oat beta-glucan reduces colitis by promoting autophagy flux in intestinal epithelial cells via EPHB6-TFEB axis. Front Pharmacol 2023; 14: 1189229.
  13. Kaczmarczyk O, Dąbek-Drobny A, Woźniakiewicz M, et al. Association between fecal levels of short-chain fatty acids and serum pro- and anti-inflammatory cytokines in patients with inflammatory bowel disease. Folia Med Cracov 2022; 62:
  14. 43-55.
  15. Fabiano GA, Shinn LM, Antunes AEC. Relationship between oat consumption, gut microbiota modulation, and short-chain fatty acid synthesis: an integrative review. Nutrients 2023; 15: 3534.
  16. Bai J, Li Y, Zhang W, et al. Source of gut microbiota determines oat b-glucan degradation and short chain fatty acid-producing pathway. Food Biosci 2021; 41: 101010.
  17. Hiengrach P, Visitchanakun P, Finkelman MA, et al. More prominent inflammatory response to pachyman than to whole-glucan particle and oat-b-glucans in dextran sulfate-induced mucositis mice and mouse injection through proinflammatory macrophages. Int J Mol Sci 2022; 23: 4026.
  18. Thies F, Masson LF, Boffetta P, Kris-Etherton P. Oats and bowel disease: a systematic literature review. Br J Nutr 2014; 112: S31-43.
  19. Nyman M, Nguyen TD, Wikman O, et al. Oat bran increased fecal butyrate and prevented gastrointestinal symptoms in patients with quiescent ulcerative colitis – randomized controlled trial. Crohn’s Colitis 360 2020; 2: otaa005.
  20. Laatikainen R, Lehto M, Mäkelä-Salmi N, et al. Randomized controlled pilot study: effect of carrageenan emulsifier on inflammation and gastrointestinal symptoms in quiescent ulcerative colitis. Food Nutr Res 2023; 67: 10.29219/fnr.v67.9575.
  21. Elmaliklis IN, Liveri A, Ntelis B, et al. Increased functional foods’ consumption and mediterranean diet adherence may have a protective effect in the appearance of gastrointestinal diseases: a case-control study. Medicines 2019; 6: 50.
  22. Davies PS, Rhodes J. Maintenance of remission in ulcerative colitis with sulphasalazine or a high-fibre diet: a clinical trial. Br Med J 1978; 1: 1524-5.
  23. Hallert C, Björck I, Nyman M, et al. Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study. Inflamm Bowel Dis 2003; 9: 116-21.
  24. Graca-Pakulska K, Błogowski W, Zawada I, et al. Endoscopic findings in the upper gastrointestinal tract in patients with crohn’s disease are common, highly specific, and associated with chronic gastritis. Sci Rep 2023; 13: 703.
  25. Gudej S, Filip R, Harasym J, et al. Clinical outcomes after oat beta-glucans dietary treatment in gastritis patients. Nutrients 2021; 13: 2791.
  26. Sub Lee H, Jae Lee K. Immunoglobulin G4-related immune responses to common food antigens in patients with ulcerative colitis and Crohn’s disease. Turk J Gastroenterol 2019; 30: 408-14.
  27. Agamennone V, Van Den Broek TJ, De Kat Angelino-Bart A, et al. Individual and group-based effects of in vitro fiber interventions on the fecal microbiota. Microorganisms 2023; 11: 2001.
  28. Liu B, Lin Q, Yang T, et al. Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. Food Funct 2015; 6: 3454-63.
  29. Żyła E, Dziendzikowska K, Gajewska M, et al. Beneficial effects of oat beta-glucan dietary supplementation in colitis depend on its molecular weight. Molecules 2019; 24: 3591.
  30. Kopiasz Ł, Dziendzikowska K, Gajewska M, et al. Time-dependent indirect antioxidative effects of oat beta-glucans on peripheral blood parameters in the animal model of colon inflammation. Antioxidants 2020; 9: 375.
  31. Suchecka D, Harasym JP, Wilczak J, et al. Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of lps-induced chronic enteritis. J Funct Foods 2015; 14: 244-54.
  32. Błaszczyk K, Wilczak J, Harasym J, et al. Impact of low and high molecular weight oat beta-glucan on oxidative stress and antioxidant defense in spleen of rats with LPS induced enteritis. Food Hydrocolloids 2015; 51: 272-80.
  33. Ji ZH, Xie WY, Zhao PS, et al. Oat peptides alleviate dextran sulfate sodium salt-induced colitis by maintaining the intestinal barrier and modulating the keap1-Nrf2 axis. Nutrients 2023; 15: 5055.
  34. Lee HJ, Kim KJ, Park S, et al. Enhancing intestinal health with germinated oats: bioinformatics and compound profiling insights into a novel approach for managing inflammatory bowel disease. Food Biosci 2024; 61: 104833.
  35. Bai J, Zhao J, AL-Ansi W, et al. Oat b-glucan alleviates DSS-induced colitis via regulating gut microbiota metabolism in mice. Food Funct 2021; 12: 8976-93.
  36. Żyła E, Dziendzikowska K, Kamola D, et al. Anti-inflammatory activity of oat beta-glucans in a Crohn’s disease model: time- and molar mass-dependent effects. Int J Mol Sci 2021; 22: 4485.
  37. Kopiasz Ł, Dziendzikowska K, Gajewska M, et al. Effects of dietary oat beta-glucans on colon apoptosis and autophagy through TLRs and dectin-1 signaling pathways – Crohn’s Disease Model Study. Nutrients 2021; 13: 321.
  38. Kopiasz Ł, Dziendzikowska K, Gromadzka-Ostrowska J. Colon expression of chemokines and their receptors depending on the stage of colitis and oat beta-glucan dietary intervention-Crohn’s Disease Model Study. Int J Mol Sci 2022; 23: 1406.
  39. Oczkowski M, Dziendzikowska K, Pasternak-Winiarska A, et al. Oat beta-glucan dietary intervention on antioxidant defense parameters, inflammatory response and angiotensin signaling in the testes of rats with TNBS-induced colitis. Nutrients 2024; 16: 2546.
  40. Chudan S, Ishibashi R, Nishikawa M, et al. Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis. Food Funct 2023; 14: 2188-99.
  41. Duan W, Zheng B, Li T, Liu R. Gut microbiota and metabolites mediate health benefits of oat and oat bran consumption in IBD mice. Nutrients 2024; 16: 4365.
  42. El-Deeb OS, Elesawy RO, Eltokhy AK, et al. Moderating gut microbiome/mitochondrial axis in oxazolone induced ulcerative colitis: the evolving role of b-glucan and/or, aldose reductase inhibitor, Fidarestat. Int J Mol Sci 2023; 24: 2711.
  43. Li M, Wang Q, Niu M, et al. Protective effects of insoluble dietary fiber from cereal bran against DSS-induced chronic colitis in mice: from inflammatory responses, oxidative stress, intestinal barrier, and gut microbiota. Int J Biol Macromol 2024; 283: 137846.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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