eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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Review paper

Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)

Tomasz Koliński, Natalia Marek-Trzonkowska, Piotr Trzonkowski, Janusz Siebert

(Cent Eur J Immunol 2016; (3): 317-323)
Heat shock proteins (HSPs) belong to the family of conservative polypeptides with a high homology of the primary structure. The uniqueness of this family lies in their ability to interact with a large number of different proteins and provide protection from cellular and environmental stress factors as molecular chaperones to keep protein homeostasis. While intracellular HSPs play a mainly protective role, extracellular or membrane-bound HSPs mediate immunological functions and immunomodulatory activity. In immune system are subsets of cells including regulatory T cells (Tregs) with suppressive functions. HSPs are implicated in the function of innate and adaptive immune systems, stimulate T lymphocyte proliferation and immunomodulatory functions, increase the effectiveness of cross-presentation of antigens, and induce the secretion of cytokines. HSPs are also important in the induction, proliferation, suppressive function, and cytokine production of Tregs, which are a subset of CD4+ T cells maintaining peripheral tolerance. Together HSPs and Tregs are potential tools for future clinical interventions in autoimmune disease.

heat shock proteins (HSPs), immune regulation, lymphocytes, regulatory T cells (Tregs)

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