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ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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vol. 10
Case report

Image-guided high-dose-rate interstitial brachytherapy technique for locally recurrent rectal cancer in perineum

Yuting Gao, Ning Wu, Zhipeng Zhao, Mingyuan He, Jie Han, Guanghui Cheng

J Contemp Brachytherapy 2018; 10, 3: 267–273
Online publish date: 2018/06/20
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The aim of the report was the evaluation of application with image-guided high-dose-rate (HDR) interstitial brachytherapy in patients undergoing conventional chemo-radiotherapy for perineal locally recurrent rectal cancer (LRRC).

Material and methods
75-year-old female patient presented with LRRC three years after total mesorectal excision (TME) surgery for rectal cancer with tubular adenocarcinoma (stage IIIB). Despite conventional chemotherapy and external beam radiotherapy, the re-recurrent lesion expanded as 4.5 × 5.5 cm2 located in perineum with skin invasion. The loco-regional recurrent tumor was treated with HDR interstitial brachytherapy under ultrasound guidance and magnetic resonance imaging-based treatment planning. The brachytherapy dose was 50 Gy in 10 fractions of 5 Gy each for 5 weeks.

Removal of the perineal LRRC was securely achieved by image-guided HDR interstitial brachytherapy technique. The refractory tumor healed uneventfully after interstitial brachytherapy without recurrence during 26 months of follow-up. The patient had good quality of life without serious complications of treatment.

Image-guided HDR interstitial brachytherapy in selected patient with LRRC in perineum is a proven, effective, and safe treatment method with relatively long-term outcome.


high-dose-rate interstitial brachytherapy, perineal recurrence, rectal cancer

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