eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 48
Review paper

Immunological mechanisms of arterial damage in pediatric patients with primary hypertension

Adam Bujanowicz
Piotr Skrzypczyk

Student Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland
Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland
Cent Eur J Immunol 2023; 48 (2): 150-157
Online publish date: 2023/05/27
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Primary hypertension is a disease that is being diagnosed with increasing frequency in pediatric patients, and many of them are found to have hypertension-mediated organ damage (HMOD), including arterial damage. The pathophysiology of primary hypertension and the formation of HMOD is multifactorial. One mechanism studied in recent years is the subclinical inflammation accompanying the elevation of blood pressure. Experimental studies, studies in adults and children, revealed the involvement of immune mechanisms in the formation of vascular lesions in the course of primary hypertension. The paper summarizes the current knowledge on this subject and points to possible therapeutic targets. Particular emphasis is placed on data from pediatric patients with primary hypertension, as a relation between arterial damage (early vascular aging) and immune system activation had already been found in children. The correct identification of immunological mechanisms may not only broaden our understanding of primary hypertension as a disease but also, more importantly, lead to the most effective methods of its treatment.

pediatric patients, subclinical inflammation, arterial damage, primary hypertension, immunological mechanisms

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