eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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SCImago Journal & Country Rank
6/2010
vol. 5
 
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abstract:
Review paper

Importance of selected polymorphisms of ABCB1 (MDR1) gene in inflammatory bowel diseases

Michał Dudarewicz
,
Małgorzata Barańska
,
Jadwiga Skrętkowicz

Przegląd Gastroenterologiczny 2010; 5 (6): 310–314
Online publish date: 2010/12/08
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Inflammatory bowl diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD) as well as unspecified forms. UC and CD are complex genetic disorders resulting from interaction between genetic, environmental, immunological and bacterial factors. One of the drug transporters, P-glycoprotein (P-gp), is thought to be involved in the pathogenesis of IBD. It is known that P-gp also constitutes a barrier against xenobiotics in the intestinal epithelial cells. P-gp is encoded by the gene ABCB1 (MDR1). ABCB1 (MDR1) polymorphisms and haplotypes may affect both the synthesis level and activity of P-gp in epithelial cells of the gastrointestinal tract. According to the data presented in this paper, it can be concluded that reduced P-gp level in the epithelium may be one of the factors responsible for the development of inflammatory bowel diseases.
keywords:

inflammatory bowel diseases, glycoprotein P, genetic polymorphisms, ABCB1 (MDR1) gene

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