eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
2/2018
vol. 43
 
Share:
Share:
more
 
 
abstract:
Clinical immunology

In vitro chromosomal radiosensitivity in patients with common variable immunodeficiency

Majid Mahmoodi
,
Hassan Abolhassani
,
Hossein Mozdarani
,
Nima Rezaei
,
Gholamreza Azizi
,
Reza Yazdani
,
Farideh Farzanfar
,
Hosein Rafiemanesh
,
Mohammad-Ali Mohagheghi
,
Kouros Divsalar
,
Rasoul Nasiri Kalmarzi
,
Asghar Ramyar
,
Asghar Aghamohammadi

(Centr Eur J Immunol 2018; 43 (2): 155-161)
Online publish date: 2018/06/30
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Common variable immunodeficiency (CVID) is one of the predominant antibody deficiency disorders, some evidence of which indicates that chromosome instability is present in these patients. An increased risk of cancer in patients with CVID has been documented. This study was undertaken to highlight radiation sensitivity in CVID patients and to clarify the genetic basis of this defect in these cases. Stimulated lymphocytes of the studied subjects were exposed to low-dose gamma-rays in the G2 phase or the G0 phase of the cell cycle and chromosomal aberrations were scored. Lymphocytes of healthy individuals, ataxia telangiectasia (AT) cases and a group of acute lymphoblastic leukemia (ALL) patients were investigated in the same way as controls. By two methods of analysis (one-way ANOVA and unpaired t-test), the CVID cases were significantly more radiosensitive than healthy controls based on the results of the G2 and the G0 assays. First-degree relatives of CVID patients were radiosensitive by the micronucleus assay which showed a significant difference as compared with normal controls (p = 0.001). In conclusion, this study may support that chromosomal radiosensitivity in CVID patients is a marker of genetic predisposition to the disease. The results might be a clue to describe the increased risk of cancer in CVID patients.
keywords:

primary immunodeficiency, common variable immunodeficiency, chromosome radio­sensitivity, acute lymphoblastic leukemia, ataxia telangiectasia

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.