eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 43
Clinical immunology

In vitro chromosomal radiosensitivity in patients with common variable immunodeficiency

Majid Mahmoodi
Hassan Abolhassani
Hossein Mozdarani
Nima Rezaei
Gholamreza Azizi
Reza Yazdani
Farideh Farzanfar
Hosein Rafiemanesh
Mohammad-Ali Mohagheghi
Kouros Divsalar
Rasoul Nasiri Kalmarzi
Asghar Ramyar
Asghar Aghamohammadi

(Centr Eur J Immunol 2018; 43 (2): 155-161)
Online publish date: 2018/06/30
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Common variable immunodeficiency (CVID) is one of the predominant antibody deficiency disorders, some evidence of which indicates that chromosome instability is present in these patients. An increased risk of cancer in patients with CVID has been documented. This study was undertaken to highlight radiation sensitivity in CVID patients and to clarify the genetic basis of this defect in these cases. Stimulated lymphocytes of the studied subjects were exposed to low-dose gamma-rays in the G2 phase or the G0 phase of the cell cycle and chromosomal aberrations were scored. Lymphocytes of healthy individuals, ataxia telangiectasia (AT) cases and a group of acute lymphoblastic leukemia (ALL) patients were investigated in the same way as controls. By two methods of analysis (one-way ANOVA and unpaired t-test), the CVID cases were significantly more radiosensitive than healthy controls based on the results of the G2 and the G0 assays. First-degree relatives of CVID patients were radiosensitive by the micronucleus assay which showed a significant difference as compared with normal controls (p = 0.001). In conclusion, this study may support that chromosomal radiosensitivity in CVID patients is a marker of genetic predisposition to the disease. The results might be a clue to describe the increased risk of cancer in CVID patients.

primary immunodeficiency, common variable immunodeficiency, chromosome radio­sensitivity, acute lymphoblastic leukemia, ataxia telangiectasia

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