Infectious factors and a process of apoptosis in the mucosa of the gastrointestinal tract

Elżbieta Maciorkowska; Ewa Ryszczuk; Maciej Kaczmarski

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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6/2009
vol. 4

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abstract:

Review paper

Infectious factors and a process of apoptosis in the mucosa of the gastrointestinal tract

Elżbieta Maciorkowska

,

Ewa Ryszczuk

,

Maciej Kaczmarski

Przegląd Gastroenterologiczny 2009; 4 (6): 293-297

Online publish date: 2009/12/22

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In gastric colonization by Helicobacter pylori, the frequency of apoptosis, a natural programmed death of a cell, increases from 2-3 to 16% (mean 8%). One of pathogenic pathways of apoptosis in the mucosa of the gastrointestinal tract is an extracellular pathway, called a receptive pathway, in which Fas receptors and an epidermal growth factor receptor (EGFR) get activated. Another pathogenic pathway is an intracellular pathway, called a mitochondrial pathway, in which mitochondrial proteins from the Bcl-2 family get activated or inhibited. The studies proved that H. pylori induced apoptosis of gastric mucosa via: cag A pathogenicity island, urease, lipopolisaccharide (LPS), cytotoxin Vac A as well as monochloramine and nitrogen oxide. A process of apoptosis induced by H. pylori results in chronic gastritis and ulcer disease, whereas inhibition of apoptosis and induction of proliferation is related to the development of a cancerous process.

keywords:

Infectious factors and a process of apoptosis in the mucosa of the gastrointestinal tract

Elżbieta Maciorkowska , Ewa Ryszczuk , Maciej Kaczmarski

apoptosis, Helicobacter pylori

Elżbieta Maciorkowska

,

Ewa Ryszczuk

,

Maciej Kaczmarski