eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
6/2009
vol. 4
 
Share:
Share:
more
 
 
abstract:
Review paper

Infectious factors and a process of apoptosis in the mucosa of the gastrointestinal tract

Elżbieta Maciorkowska
,
Ewa Ryszczuk
,
Maciej Kaczmarski

Przegląd Gastroenterologiczny 2009; 4 (6): 293-297
Online publish date: 2009/12/22
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
In gastric colonization by Helicobacter pylori, the frequency of apoptosis, a natural programmed death of a cell, increases from 2-3 to 16% (mean 8%). One of pathogenic pathways of apoptosis in the mucosa of the gastrointestinal tract is an extracellular pathway, called a receptive pathway, in which Fas receptors and an epidermal growth factor receptor (EGFR) get activated. Another pathogenic pathway is an intracellular pathway, called a mitochondrial pathway, in which mitochondrial proteins from the Bcl-2 family get activated or inhibited. The studies proved that H. pylori induced apoptosis of gastric mucosa via: cag A pathogenicity island, urease, lipopolisaccharide (LPS), cytotoxin Vac A as well as monochloramine and nitrogen oxide. A process of apoptosis induced by H. pylori results in chronic gastritis and ulcer disease, whereas inhibition of apoptosis and induction of proliferation is related to the development of a cancerous process.
keywords:

apoptosis, Helicobacter pylori

Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe