eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
2/2018
vol. 43
 
Share:
Share:
abstract:
Clinical immunology

Interleukin 1-β, interleukin-1 receptor antagonist and vitamin D levels in children with atopic dermatitis

Edyta Machura
,
Maria Szczepańska
,
Bogdan Mazur
,
Katarzyna Ziora
,
Alicja Kasperska-Zajac

(Centr Eur Immunol 2018; 43 (2): 180-185)
Online publish date: 2018/06/30
View full text Get citation
 
PlumX metrics:
Introduction
Among the broad spectrum of cytokines, interleukin 1- (IL-1) has been implicated in induction and subsequent aggravation of skin lesions in atopic dermatitis (AD). A considerable body of evidence suggests that vitamin D status also influences the risk and/or severity of AD.

Material and methods
Fifty-seven children suffering from mild to severe AD were enrolled in the study. The control group consisted of 33 matched healthy children. In all the children serum concentrations of IL-1/IL-1F2 and the interleukin-1 receptor antagonist IL-Ra/1F3 were measured. Serum 25(OH)D concentration was obtained for 49 patients with AD and all healthy children.

Results
In children with AD 59.2% of children had insufficiency, 24.5% had deficiency and 16.3% had a sufficient serum 25(OH)D level. In the control group 26.5%, 52.9% and 20% of participants had insufficiency/deficiency/sufficiency of 25(OH)D, respectively. The severity of AD was positively correlated with total IgE level, percentage and absolute count of eosinophils and IL-1Ra. IL-1 correlated with IL-1Ra.

Conclusions
In children with AD the serum vitamin D level was lower than in healthy children. The correlation between severity of AD and IL-1Ra may prove that inflammasome-dependent IL-1 is involved in immunopathogenesis of the disease. Further studies are needed on a larger population of children to confirm the role of this cytokine in development of AD.

keywords:

children, atopic dermatitis, vitamin D, interleukin 1-, IL-1Ra

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.