eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank

vol. 43
Clinical immunology

Interleukin 1-β, interleukin-1 receptor antagonist and vitamin D levels in children with atopic dermatitis

Edyta Machura, Maria Szczepańska, Bogdan Mazur, Katarzyna Ziora, Alicja Kasperska-Zajac

(Centr Eur Immunol 2018; 43 (2): 180-185)
Online publish date: 2018/06/30
View full text
Get citation
JabRef, Mendeley
Papers, Reference Manager, RefWorks, Zotero
Among the broad spectrum of cytokines, interleukin 1- (IL-1) has been implicated in induction and subsequent aggravation of skin lesions in atopic dermatitis (AD). A considerable body of evidence suggests that vitamin D status also influences the risk and/or severity of AD.

Material and methods
Fifty-seven children suffering from mild to severe AD were enrolled in the study. The control group consisted of 33 matched healthy children. In all the children serum concentrations of IL-1/IL-1F2 and the interleukin-1 receptor antagonist IL-Ra/1F3 were measured. Serum 25(OH)D concentration was obtained for 49 patients with AD and all healthy children.

In children with AD 59.2% of children had insufficiency, 24.5% had deficiency and 16.3% had a sufficient serum 25(OH)D level. In the control group 26.5%, 52.9% and 20% of participants had insufficiency/deficiency/sufficiency of 25(OH)D, respectively. The severity of AD was positively correlated with total IgE level, percentage and absolute count of eosinophils and IL-1Ra. IL-1 correlated with IL-1Ra.

In children with AD the serum vitamin D level was lower than in healthy children. The correlation between severity of AD and IL-1Ra may prove that inflammasome-dependent IL-1 is involved in immunopathogenesis of the disease. Further studies are needed on a larger population of children to confirm the role of this cytokine in development of AD.


children, atopic dermatitis, vitamin D, interleukin 1-, IL-1Ra

Kuo IH, Yoshida T, De Benedetto A, Beck LA (2013): The cutaneous innate immune response in patients with atopic dermatitis. J Allergy Clin Immunol 131: 266-278.
Boguniewicz M, Leung DY (2011): Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev 242: 233-246.
Schlapbach C, Simon D (2014): Update of skin allergy. Allergy 69:1571-1581.
Abramovits W, Rivas Bejarano JJ, Valdecantos WC (2013): Role of interleukin 1 in atopic dermatitis. Dermatol Clin 31: 437-444.
Yamanaka K, Mizutani H (2015): “Inflammatory skin march”: IL-1-mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events. J Allergy Clin Immunol 136: 823-824.
van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA (2011): Inflammasome activation and IL-1 and IL-18 processing during infection. Trends Immunol 32: 110-116.
Smith DE, Mason DR, Beck PL, Muruve DA (2012): Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation anddiseases. J Innate Immun 4: 16-30.
Contassot E, Beer HD, French LE (2012): Interleukin-1, inflammasomes,autoinflammation and the skin. Swiss Med Wkly 142: w13590
9. Krause K, Metz M, Makris M, et al. (2012): The role of interleukin-1 in allergy-related disorders. Curr Opin Allergy Clin Immunol 12: 477-484.
Nambu A, Nakae S (2010): IL-1 and Allergy. Allergol Int 59: 125-135.
Machura E, Szczepańska M, Mazur B, et al. (2013): Interleukin 1-, interleukin-1 receptor antagonist, and interleukin 18 in children with acute spontaneous urticaria. Biomed Res Int 2013: 605262.
Vestita M, Filoni A, Congedo M, et al. (2015): Vitamin D and atopic dermatitis in childhood. J Immunol Res 2015: 257879.
Oh JW. The clinical impact of vitamin D in children with atopic dermatitis (2013): Allergy Asthma Immunol Res 5: 179-180.
Benson AA, Toh JA, Vernon N, Jariwala SP (2012): The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy 67: 296-301.
Mostafa WZ, Hegazy RA (2015): Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res 6: 793-804.
Hanifin JM, Rajka G (1980): Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 92: 44-47.
European Task Force on Atopic Dermatitis (1993): Severity scoring of atopic dermatitis: the SCORAD index. Dermatology 186: 23-31.
Samochocki Z, Bogaczewicz J, Jeziorkowska R, et al. (2013): Vitamin D effects in atopic dermatitis. J Am Acad Dermatol 69: 238-244.
Akan A, Azkur D, Ginis T, et al. (2013): Vitamin D level in children is correlated with severity of atopic dermatitis but only in patients with allergic sensitizations. Pediatr Dermatol 30: 359-363.
MesquitaKde C, Igreja AC, Costa IM (2013): Atopic dermatitis and vitamin D: facts and controversies. An Bras Dermatol 88: 945-953.
Palmer DJ (2015): Vitamin D and the Development of Atopic Eczema. J Clin Med 4: 1036-1050.
Wang SS, Hon KL, Kong AP, et al. (2014): Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatr Allergy Immunol 25: 30-35.
Peroni DG, Piacentini GL, Cametti E, et al. (2011): Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol 164: 1078-1082.
El Taieb MA, Fayed HM, Aly SS, Ibrahim AK (2013): Assessment of serum 25-hydroxy-vitamin D levels in children with atopic dermatitis: correlation with SCORAD index. Dermatitis 24: 296-301.
Baek JH, Shin YH, Chung IH, et al. (2014): The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy. J Pediatr 165: 849-854.e1.
Kanda N, Hau CS, Tada Y, et al. (2012): Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M. Allergy 67: 804-812.
Chiu YE, Havens PL, Siegel DH, et al. (2013): Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity. J Am Acad Dermatol 69: 40-46.
Javanbakht MH, Keshavarz SA, Djalali M, et al. (2011): Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis. J Dermatol Treat 22: 144-150.
Hata TR, Audish D, Kotol P, et al. (2014): A randomized controlled double-blind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis.J Eur Acad Dermatol Venereol 28: 781-789.
Chawes BL, Bønnelykke K, Jensen PF, et al. (2014): Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study. PLoS One 9: e99856.
Bäck O, Blomquist HK, Hernell O, Stenberg B (2009): Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol 89: 28-32.
Baeke F, Takiishi T, Korf H, et al. (2010): Vitamin D: modulator of the immune system. Curr Opin Pharmacol 10: 482-496.
Kong J, Grando SA, Li YC (2006): Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes. J Immunol 176: 3780-3787.
Grudet C, Malm J, Westrin A, Brundin L (2014): Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood. Psychoneuroendocrinology 50: 210-219.
Arend WP (2002): The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev 13: 323-340.
Kezic S, O’Regan GM, Lutter R, et al. (2012): Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol 129: 1031-1039.e1
Abdel Hay RM, Ibrahim NF, Metwally D, Rashed LA (2013): The role of interleukin-1  and interleukin-33 in atopic dermatitis. Our Dermat Online 4: 11-14.
Nutan FN, Kanwar AJ, Parsad D (2012): The effect of topically applied corticosteroids on interleukin 1 levels in patients with atopic dermatitis. J Eur Acad Dermatol Venereol 26: 1020-1022.
Kopfnagel V, Wittmann M, Werfel T (2011): Human keratinocytes express AIM2 and respond to dsDNA with IL-1 secretion. Exp Dermatol 20: 1027-1029.
Enk AH, Katz SI (1992): Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci U S A 89: 1398-1402.
Dombrowski Y, Peric M, Koglin S, et al. (2012): Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes. Allergy 67: 1400-1407.
Boehm KD, Yun JK, Strohl KP, et al. (1996): In situ changes in the relative abundance of human epidermal cytokine messenger RNA levels following exposure to the poison ivy/oak contact allergen urushiol. Exp Dermatol 5: 150-160.
Thyssen JP, Kezic S (2014): Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 134: 792-799.
Niebuhr M, Baumert K, Heratizadeh A, et al. (2014): Impaired NLRP3 inflammasome expression and function in atopic dermatitis due to Th2 milieu. Allergy 69: 1058-1067.
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe