Gastroenterology Review
eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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Original paper

Irritable bowel syndrome clinical trials: getting the IBS Severity Scoring System responder rate right

Henning Sommermeyer
1
,
Krzysztof Chmielowiec
2
,
Paulina Wojtyła-Buciora
1
,
Malgorzata Bernatek
1
,
Pawel Olszewski
1
,
Zygmunt Kopczynski
1
,
Jacek Piatek
1

  1. Department of Medicine and Health Sciences, Calisia University, Kalisz, Poland
  2. Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Poland
Gastroenterology Review
DOI: https://doi.org/10.5114/pg.2025.156735
Online publish date: 2025/12/07
Article file
- Irritable bowel syndrome.pdf  [0.09 MB]
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1. Ford AC, Sperber AD, Corsetti M, Camilleri M. Irritable bowel syndrome. Lancet 2020; 396: 1675-88.
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8. Streiner DL. Breaking up is hard to do: the heartbreak of dichotomizing continuous data. Can J Psychiatry 2002; 47: 262-6.
9. Sommermeyer H, Chmielowiec K, Bernatek M, et al. Effectiveness of a balanced nine-strain synbiotic in primary-care irritable bowel syndrome patients-a multi-center, randomized, double-blind, placebo-controlled trial. Nutrients 2024; 16: 1503.
10. Fawcett T. An introduction to ROC analysis. Pattern Recognition Letters 2006; 27: 861-74.
11. Mandrekar JN. Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol 2010; 5: 1315-6.
12. Nahm FS. Receiver operating characteristic curve: overview and practical use for clinicians. Korean J Anesthesiol 2022; 75: 25-36.
13. López-Ratón M, Rodríguez-Álvarez MX, Cadarso-Suárez C, Gude-Sampedro F. Optimal cutpoints: an R Package for selecting optimal cutpoints in diagnostic tests. J Stat Softw 2014; 61: 1-36.
14. Spiegel B, Bolus R, Harris LA, et al. Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale. Aliment Pharmacol Ther 2009; 30: 1159-70.
Copyright: © 2025 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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