Laser For complex coronary Artery lesion pReparatiOn: the results of the pilot FARO study

Vittorio Ambrosini; Pietro Armigliato; Antonio Colombo; Massimo Napodanno; Luca Golino

doi:10.5114/aic.2025.151732

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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2/2025
vol. 21

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abstract:

Original paper

Laser For complex coronary Artery lesion pReparatiOn: the results of the pilot FARO study

Vittorio Ambrosini

^{1, 2}

,

Pietro Armigliato

^{1, 3}

,

Antonio Colombo

^{1, 4}

,

Massimo Napodanno

^{1, 5}

,

Luca Golino

^{1, 6}

CLS: Cardiovascular Laser Society Foundation, Verona, Italy
UOC Cardiologia -UTIC- Ospedale Frangipane Ariano Irpino (ASL AV), Italy
Cardiovascular Department, University of Verona, Verona, Italy
Centro Cuore Columbus, Milano, Italy
UOSD Emodinamica e Cardiologia Interventistica, Dipartimento Strutturale Aziendale Cardio-Toraco-Vascolare, Azienda Ospedaliera Universitaria di Padova, Italy
UOC Cardiologia-UTIC - Ospedale San Giuseppe Moscati - Aversa (ASL CE), Italy

Adv Interv Cardiol 2025; 21, 2 (80): 185–190

DOI: https://doi.org/10.5114/aic.2025.151732

Online publish date: 2025/05/31

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Introduction:
When used by experienced operators, excimer laser coronary artery angioplasty is a well-established therapy that can be used during percutaneous coronary intervention to treat a wide range of coronary lesions including heavily calcified stenosis.

Aim:
This study sought to analyze the safety and effectiveness of laser angioplasty with the Auryon laser system for the treatment of heavily calcified coronary lesions.

Material and methods:
A pragmatic sample of 20 patients with heavily calcified stenosis gave informed consent to participate in the study; we evaluated patient characteristics including age, cardiovascular risk factors, angiographic data (lesion complexity, number of stenoses, chronic total occlusion), calcium arch, thrombolysis in myocardial infarction (TIMI) flow before and after revascularization, percutaneous coronary intervention (PCI) success, and acute-stent thrombosis.

Results:
A total of 20 subjects (20 lesions) were enrolled. A successful result, defined as < 30% residual stenosis and TIMI 3 flow after PCI, was achieved in 95% of cases.

Conclusions:
This study introduced the successful use of this innovative device to treat high calcium and complex epicardial stenosis in 20 patients. The positive impressions include the ease of use and the safety and effectiveness in the treatment of severely calcified lesions.

keywords:

Laser For complex coronary Artery lesion pReparatiOn: the results of the pilot FARO study

Vittorio Ambrosini 1, 2 , Pietro Armigliato 1, 3 , Antonio Colombo 1, 4 , Massimo Napodanno 1, 5 , Luca Golino 1, 6

calcific coronary lesions, complex percutaneous coronary interventions, excimer laser coronary atherectomy

Vittorio Ambrosini

^{1, 2}

,

Pietro Armigliato

^{1, 3}

,

Antonio Colombo

^{1, 4}

,

Massimo Napodanno

^{1, 5}

,

Luca Golino

^{1, 6}