Ta strona używa pliki cookies, w celu polepszenia użyteczności i funkcjonalności oraz w celach statystycznych. Dowiedz się więcej w Polityce prywatności.
Korzystając ze strony wyrażasz zgodę na używanie plików cookies, zgodnie z aktualnymi ustawieniami przeglądarki.
Akceptuję wykorzystanie plików cookies
Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Share:
Share:
Original paper

Long non-coding RNA GAS5 alleviates inflammation in acute gouty arthritis via targeting miR-485-5p

Meng Xie
1
,
Fang Zhou
1
,
Lan Li
1

  1. Department of Rheumatology and Immunology, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Hebei Port Group Co., Ltd., Qinhuangdao 066000, China
Cent Eur J Immunol 2025; 50 (2)
Online publish date: 2025/06/12
Article file
Get citation
 
PlumX metrics:
 
1. Stewart S, Dalbeth N, Gaffo A (2021): The challenge of gout flare measurement. Best Pract Res Clin Rheumatol 35: 101716.
2. Garcia-Guillen A, Stewart S, Su I, et al. (2022): Gout flare severity from the patient perspective: A qualitative interview study. Arthritis Care Res 74: 317-323.
3. Fu W, Ge M, Li J (2023): Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies. J Transl Med 21: 261.
4. Mattiuzzi C, Lippi G (2020): Recent updates on worldwide gout epidemiology. Clin Rheumatol 39: 1061-1063.
5. Ni Z, Xiao Q, Xia Z, et al. (2023): Electroacupuncture for acute gouty arthritis: a systematic review and meta-analysis of randomized controlled trials. Front Immunol 14: 1295154.
6. Dalbeth N, Choi HK, Terkeltaub R (2017): Review: Gout: A roadmap to approaches for improving global outcomes. Arthritis Rheumatol 69: 22-34.
7. Mercer TR, Mattick JS (2013): Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol 20: 300-307.
8. Ma H, Hao Y, Dong X, et al. (2012): Molecular mechanisms and function prediction of long noncoding RNA. ScientificWorldJournal 2012: 541786.
9. Xu YT, Leng YR, Liu MM, et al. (2020): MicroRNA and long noncoding RNA involvement in gout and prospects for treatment. Int Immunopharmacol 87: 106842.
10. Guo Y, Li G, Gao L, et al. (2021): Exaggerated renal fibrosis in lncRNA Gas5-deficient mice after unilateral ureteric obstruction. Life Sci 264: 118656.
11. Zhang Y, Xu S, Huang E, et al. (2018): MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. Int J Mol Med 41: 3699-3708.
12. Zhou Y, Li S, Chen P, et al. (2019): MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2. Artif Cells Nanomed Biotechnol 47: 1766-1771.
13. Alivernini S, Gremese E, McSharry C, et al. (2017): Micro-RNA-155-at the critical interface of innate and adaptive immunity in arthritis. Front Immunol 8: 1932.
14. Tsai CH, Liu SC, Chung WH, et al. (2020): Visfatin increases VEGF-dependent angiogenesis of endothelial progenitor cells during osteoarthritis progression. Cells 9: 1315.
15. Cai X, Yao Y, Ren F, et al. (2024): circTldc1 increases Tldc1 expression by targeting miR-485-5p to promote fibroblast-like synoviocytes proliferation in collagen-induced arthritis. Exp Cell Res 435: 113928.
16. Zuo X, Li W, Yan X, et al. (2021): Long non coding RNA LINC01224 promotes cell proliferation and inhibits apoptosis by regulating AKT3 expression via targeting miR 485 5p in endometrial carcinoma. Oncol Rep 46: 186.
17. Ebrahimiyan H, Rezaei N, Vojdanian M, et al. (2019): microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients. Int J Rheum Dis 22: 1107-1114.
18. Chen HO, Zhang L, Tang ZY, et al. (2018): MiR-485-5p promotes the development of osteoarthritis by inhibiting cartilage differentiation in BMSCs. Eur Rev Med Pharmacol Sci 22: 3294-3302.
19. Wilson L, Saseen JJ (2016): Gouty arthritis: A review of acute management and prevention. Pharmacotherapy 36: 906-922.
20. Pope RM, Tschopp J (2007): The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum 56: 3183-3188.
21. Mitroulis I, Kambas K, Ritis K (2013): Neutrophils, IL-1, and gout: is there a link? Semin Immunopathol 35: 501-512.
22. di Giovine FS, Malawista SE, Thornton E, et al. (1991): Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest 87: 1375-1381.
23. Russo RC, Garcia CC, Teixeira MM, et al. (2014): The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases. Expert Rev Clin Immunol 10: 593-619.
24. Zhao Q, Xia N, Xu J, et al. (2023): Pro-inflammatory of PRDM1/SIRT2/NLRP3 axis in monosodium urate-induced acute gouty arthritis. J Innate Immun 15: 614-628.
25. Li G, Zhang H, Ma H, et al. (2021): MiR-221-5p is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting IL-1. Int J Rheum Dis 24: 335-340.
26. Tu B, Song K, Zhou Y, et al. (2023): METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation. Pharmacol Res 194: 106840.
27. Zhou Z, Chen J, Huang Y, et al. (2021): Long noncoding RNA GAS5: A new factor involved in bone diseases. Front Cell Dev Biol 9: 807419.
28. Li Y, Geng Y, Zhou B, et al. (2021): Long non-coding RNA GAS5 worsens coronary atherosclerosis through micro- RNA-194-3p/TXNIP axis. Mol Neurobiol 58: 3198-3207.
29. Zhang Y, Chen S, Yuan M, et al. (2022): Gout and diet: A comprehensive review of mechanisms and management. Nutrients 14: 3525.
30. Chen T, Meng Y, Zhou Z, et al. (2023): GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis. Cell Death Differ 30: 1829-1848.
31. Ling H, Li Q, Duan ZP, et al. (2021): LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury. Am J Physiol Cell Physiol 321: C117-C133.
32. Mao S, Luo X, Zeng W (2020): GAS5/MiR-135b axis is a potential target for myocardial infarction. Int J Cardiol 311: 21.
33. O’Connell RM, Rao DS, Chaudhuri AA, et al. (2010): Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10: 111-122.
34. Jin HM, Kim TJ, Choi JH, et al. (2014): MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis. Arthritis Res Ther 16: R88.
35. Dalbeth N, Pool B, Shaw OM, et al. (2015): Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. Ann Rheum Dis 74: 786-790.
36. Wang Y, Xu D, Wang B, et al. (2015): Could microRNAs be regulators of gout pathogenesis? Cell Physiol Biochem 36: 2085-2092.
37. Yang Z, Lin SD, Zhan F, et al. (2021): LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis. Autoimmunity 54: 13-22.
38. Peng T, Ji D, Jiang Y (2021): Long non-coding RNA GAS5 suppresses rheumatoid arthritis progression via miR-128-3p/HDAC4 axis. Mol Cell Biochem 476: 2491-2501.
39. Zhang W, Li B, Xia N, et al. (2021): lncRNA GAS5 suppresses rheumatoid arthritis by inhibiting miR-361-5p and increasing PDK4. Biochem Biophys Res Commun 583: 7-13.
40. Xu M, Wu R, Zhang L, et al. (2020): Decreased miR-485-5p contributes to inflammatory pain through post-transcriptional upregulation of ASIC1 in rat dorsal root ganglion. J Pain Res 13: 3013-3022.
Copyright: © 2025 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2025 Termedia Sp. z o.o.
Developed by Bentus.