Melanin and Vitamin D: Unravelling the Mechanism and
Coalition of Two Archaic Biomolecules in Human Evolution and Health

Sumit Maitra; Arkopala Bose; Diptendu Chatterjee; Arup Bandyopadhyay

doi:10.5114/dr.2025.155989

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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4/2025
vol. 112

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Artykuł przeglądowy

Melanin and Vitamin D: Unravelling the Mechanism and Coalition of Two Archaic Biomolecules in Human Evolution and Health

Sumit Maitra

^{1, 2}

,

Arkopala Bose

¹

,

Diptendu Chatterjee

¹

,

Arup R. Bandyopadhyay

¹

Department of Anthropology, University of Calcutta, Kolkata, West Bengal, India
Sociological Research Unit (SRU), Indian Statistical Institute, Giridih, Jharkhand, India

Dermatol Rev/Przegl Dermatol 2025, 112, 235–242

DOI: https://doi.org/10.5114/dr.2025.155989

Data publikacji online: 2025/10/30

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Metryki PlumX:

Melanin and vitamin D share a unique relationship. Human skin pigmentation has changed throughout the course of evolution to provide protection from intense ultraviolet radiation (UVR) while still allowing for cutaneous vitamin D synthesis. Vitamin D is essential for maintaining human health, and its synthesis occurs in the skin upon exposure to ultraviolet B radiation. Moreover, when isolated human populations migrated to radically different climatic environments with exceptionally low or high UVB exposure, pigmentation phenotypes evolved repeatedly as a result of distinct genetic processes. Rapid changes in migratory patterns and lifestyle factors further contributed to variations in human skin pigmentation and, together with environmental influences, led to vitamin D deficiency. Against this backdrop, the present review aims to untangle the intertwined roles that two ancient biomolecules, melanin and vitamin D, have played in human evolution and health.

Indeks osobowy

Melanin and Vitamin D: Unravelling the Mechanism and Coalition of Two Archaic Biomolecules in Human Evolution and Health

Sumit Maitra 1, 2 , Arkopala Bose 1 , Diptendu Chatterjee 1 , Arup R. Bandyopadhyay 1

Sumit Maitra

^{1, 2}

,

Arkopala Bose

¹

,

Diptendu Chatterjee

¹

,

Arup R. Bandyopadhyay

¹