eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2017
vol. 42
 
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abstract:
Experimental immunology

MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6Clow myeloid-derived suppressor cells in asthmatic mice

Hua Ma
,
Shujun Guo
,
Yulan Luo
,
Yimeng Wang
,
Helong Wang
,
Jing He
,
Jie Tang
,
Lin Shen
,
Chuanwang Song

(Cent Eur J Immunol 2017; 42 (1): 30-38)
Online publish date: 2017/05/08
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miR-20b is a member of the miR-106a-363 gene cluster, which has been shown to play an important role in a variety of diseases, including cancer, inflammation, and autoimmune diseases. Our previous study indicated that miR-20b has an inhibitory effect on airway inflammation in asthmatic mice, but the exact mechanism is unclear. In this study, we report that the ratio of CD11b+Ly6G+Ly6Clow cells, but not the amount of CD11b+Ly6C+Ly6G– cells, was increased in the lung tissue of asthmatic mice after intranasal instillation with miR-20b mimics, while Th2-type cytokines (interleukin (IL)-4 and IL-13) were significantly decreased in the bronchoalveolar lavage fluid. In addition, the transcription factor CREB regulated the expression of miR-20b. Our findings suggest that miR-20b can induce the accumulation of myeloid-derived suppressor cells in the lungs of asthmatic mice, which may be a mechanism by which miR-20b inhibits airway inflammation in asthmatic mice. Thus, miR-20b may be used as a target for the effective treatment of asthma in the future.
keywords:

asthma, MiR-20b, myeloid-derived suppressor cells (MDSCs), allergic airway inflammation

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