Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation

Witold Streb; Alicja Pawlus; Kacper Kolebacz; Marta Jędrzejowska; Beata Średniawa; Piotr Chodór; Ewa Markowicz-Pawlus; Zbigniew Kalarus

doi:10.5114/aic.2025.156753

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

Current Issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Send email

Copy url:

abstract:

Original paper

Myocardial strain and work in patients with severe aortic stenosis and mitral regurgitation undergoing transcatheter aortic valve implantation

Witold Streb

^{1, 2}

,

Alicja Pawlus

³

,

Kacper Kolebacz

³

,

Marta Jędrzejowska

³

,

Beata Średniawa

^{1, 2}

,

Piotr Chodór

^{1, 2}

,

Ewa Markowicz-Pawlus

²

,

Zbigniew Kalarus

^{1, 2}

Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
Silesian Centre for Heart Diseases, Zabrze, Poland
Student Scientific Club at the Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland

Adv Interv Cardiol

DOI: https://doi.org/10.5114/aic.2025.156753

Online publish date: 2025/12/06

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Streb W, Pawlus A, Kolebacz K, et al. Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2025. doi:10.5114/aic.2025.156753.

APA

Streb, W., Pawlus, A., Kolebacz, K., Jędrzejowska, M., Średniawa, B.,  & Chodór, P. et al. (2025). Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. https://doi.org/10.5114/aic.2025.156753

Chicago

Streb, Witold, Alicja Pawlus, Kacper Kolebacz, Marta Jędrzejowska, Beata Średniawa, Piotr Chodór,  and Ewa Markowicz-Pawlus et al. 2025. "Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. doi:10.5114/aic.2025.156753.

Harvard

Streb, W., Pawlus, A., Kolebacz, K., Jędrzejowska, M., Średniawa, B., Chodór, P., Markowicz-Pawlus, E.,  and Kalarus, Z. (2025). Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. https://doi.org/10.5114/aic.2025.156753

MLA

Streb, Witold et al. "Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 2025. doi:10.5114/aic.2025.156753.

Vancouver

Streb W, Pawlus A, Kolebacz K, Jędrzejowska M, Średniawa B, Chodór P et al. Myocardial strain and work in patients with severe
aortic stenosis and mitral regurgitation undergoing
transcatheter aortic valve implantation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2025. doi:10.5114/aic.2025.156753.

Introduction
Non-invasive myocardial work assessment, using global left ventricular longitudinal strain (GLS), has emerged as a key tool for evaluating left ventricular (LV) function independent of loading conditions.

Aim
This study aims to evaluate the effects of concomitant mitral regurgitation (MR) on myocardial work parameters in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI).

Material and methods
A prospective registry study was conducted on 95 consecutive patients with severe AS, 28% of whom had moderate to severe MR. Echocardiographic data, including GLS and myocardial work parameters (global constructive work [GCW], global wasted work [GWW], and global work efficiency [GWE]), were collected prior to TAVI.

Results
While GLS values did not significantly differ between MR severity groups, GCW and GWE showed significant variation. The lowest GCW values were observed in patients with severe MR (1483.3 ±282.7 mm Hg%) and the highest in those with moderate MR (2114.9 ±534.6 mm Hg%) (p = 0.01). Similarly, lower GWE values were observed in patients with severe MR compared to the other groups (p = 0.02). No significant differences were found for GWW (p = 0.21).

Conclusions
The findings suggest that while GLS remains relatively consistent across different MR severity groups, GCW and GWE tend to decrease in patients with severe MR. This observation may indicate that GCW is a more responsive marker of myocardial function in the presence of concomitant MR.

keywords:

Myocardial strain and work in patients with severe aortic stenosis and mitral regurgitation undergoing transcatheter aortic valve implantation

Witold Streb 1, 2 , Alicja Pawlus 3 , Kacper Kolebacz 3 , Marta Jędrzejowska 3 , Beata Średniawa 1, 2 , Piotr Chodór 1, 2 , Ewa Markowicz-Pawlus 2 , Zbigniew Kalarus 1, 2

myocardial work, aortic stenosis, mitral regurgitation

Witold Streb

^{1, 2}

,

Alicja Pawlus

³

,

Kacper Kolebacz

³

,

Marta Jędrzejowska

³

,

Beata Średniawa

^{1, 2}

,

Piotr Chodór

^{1, 2}

,

Ewa Markowicz-Pawlus

²

,

Zbigniew Kalarus

^{1, 2}