Neuroblastoma presenting as haemophagocytic lymphohistiocytosis

Monika Pogorzala

doi:10.5114/polp.2025.149477

eISSN: 2300-8660
ISSN: 0031-3939

Pediatria Polska - Polish Journal of Paediatrics

Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Rada naukowa Bazy indeksacyjne Kontakt Zasady publikacji prac Standardy etyczne i procedury

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Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2025
vol. 100

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Opis przypadku

Neuroblastoma presenting as haemophagocytic lymphohistiocytosis

Monika Pogorzala

¹

Department of Paediatric Haematology and Oncology, Jurasz University Hospital 1, Collegium Medicum, Nicolaus Copernicus University Toruń, Bydgoszcz, Poland

Pediatr Pol 2025; 100 (1): 109-114

DOI: https://doi.org/10.5114/polp.2025.149477

Data publikacji online: 2025/04/15

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Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome of excessive activation of the immune system, which can be primary (genetically determined) or secondary (acquired). Secondary forms are most often triggered by infections, but also by autoimmune processes, neoplastic diseases, drugs, and metabolic diseases. Secondary HLH associated with malignancy occurs more often in adults, mainly in the course of lymphomas and leukaemia. It is rarely induced by solid tumours but can develop during chemotherapy. The presented case of a 1.5-year-old child reflects a very rare situation when symptoms of haemophagocytic syndrome turned out to be the primary manifestation of a non-haematological proliferative disease.

Neuroblastoma presenting as haemophagocytic lymphohistiocytosis

Monika Pogorzala 1

Monika Pogorzala

¹