eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 41
Clinical immunology

Neutrophil to lymphocyte ratio is associated with proximal/middle segment of the LAD lesions in patients with ST segment elevation infarction

Ozlem Arican Ozluk
Mustafa Yılmaz
Dursun Topal
Erhan Tenekecioglu
Tezcan Peker
Selcuk Kanat
Kemal Karaagac
Fahriye Vatansever
Utku Parlak

(Cent Eur J Immunol 2016; 41 (4): 386-391)
Online publish date: 2017/01/24
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Introduction: Neutrophil to lymphocyte ratio (NLR) was revaled to have a close relation with atherosclerotic cardiovascular disease. The relationship between NLR and culprit plaque localization has never been studied.

Aim of the study: To evaluate the association between NLR and unstable plaque localization of left anterior descending artery (LAD) in anterior miyocardial infarction patients.

Material and methods: Patients admitted to our hospital with acute anterior STEMI were included. Fifhy-eight patients who have single-vessel disease at LAD and their hematological parameters were analyzed retrospectively. Proximal segment of LAD lesions were groupped as Group I and mid segment of the LAD lesion groupped as Group II. The groups were compared according to their NLR and other parameters.

Results: Between group I (n = 41, mean age 52.5 ±12.7) and group II (n = 17, mean ages 52.0 ±10.8); NLR, were significantly higher in group I compared to the group II (6.9 ±5.6 vs. 3.3 ±2.0, p = 0.01). In group I, left ventricular ejection fraction (LVEF) was significantly lower (p = 0.02). In correlation analyzes, NLR was positively correlated with CK MB (r = 0.32, p = 0.01) and negatively correlated with LVEF (r = –0.28, p = 0.03).

Conclusions: The present study demonstrated that anterior myocardial infarction patients with high NLR had a greater possibility having proximal culprit lesion on the LAD. Therefore NLR can be used as a useful tool to culprit plaque localization in patients with acute miyocardial infarction patients.


coronary artery disease, neutrophil to lymphocyte ratio, acute coronary syndrome

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