eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
Current Issue Archive Supplements Articles in Press Journal Information Aims and Scope Editorial Office Editorial Board Register as Author Register as Reviewer Instructions for Authors Abstracting and indexing Subscription Advertising Information Links
SCImago Journal & Country Rank

Interview with Professor Janusz Skowronek
ABS 2015
2/2017
vol. 9
 
Share:
Share:
more
 
 
abstract:
Original paper

Parameters predicting for prostate specific antigen response rates at one year post low-dose-rate intraoperative prostate brachytherapy

Kevin Martell, Tyler Meyer, Michael Sia, Steve Angyalfi, Siraj Husain

J Contemp Brachytherapy 2017; 9, 2: 99–105
Online publish date: 2017/04/13
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Purpose: To develop a model for prostate specific antigen (PSA) values at one year among patients treated with intraoperatively planned 125I prostate brachytherapy (IOPB).

Material and methods: Four hundred and deven patients treated with IOPB for prostate adenocarcinoma were divided into four groups: those with PSA values ≥ 3 ng/ml; < 3 and ≥ 2; < 2 and ≥ 1 or PSA < 1 between 10.5 and 14.5 months post implantation (1yPSA). Ordinal regression analysis was then performed between patient, tumor, and treatment characteristics. 1yPSA values were also compared with toxicity outcomes.

Results: Median 1yPSA was 0.77 (0.04-17.36). Thirty-two patients (8%) had a PSA ≥ 3; 35 (9%) had PSA < 3, ≥ 2; 87 (21%) had PSA < 2, ≥ 1, and most patients 254 (62%) had PSA < 1. PSA response was independent of gland volume, Gleason score, clinical stage, seed activity, V90, V200, D90, or number of needles and seeds used. Older patients had significantly lower 1yPSA; median ages 65.1 (46.5-81.0), 62.1 (50.4-79.5), 60.5 (47.1-80.3), and 58.1 (45.1-74.2) years for each of the 1yPSA groups respectively (p < 0.001). Also, both implant V150 (p < 0.001) and initial PSA values (p = 0.04) were predictive of 1yPSA values. There was no correlation between 1yPSA values and toxicity encountered.

Conclusions: PSA response at 1 year post IOPB appears to be dependent on patient age, initial PSA, and implant V150. Our results provide reassurance that parameters other than biochemical failure influence 1yPSA values.
keywords:

brachytherapy, LDR, prostate cancer, PSA, seeds

references:
Marshall R, Buckstein M, Stone N et al. Treatment outcomes and morbidity following definitive brachytherapy with or without external beam radiation for the treatment of localized prostate cancer: 20-year experience at Mount Sinai Medical Center. Urol Oncol 2014; 32: 38.e1-7.
Kupelian P, Potters L, Khuntia D et al. Radical prostatectomy, external beam radiotherapy < 72 Gy, external beam radiotherapy ≥ 72 Gy, permanent seed implantation, or combined seeds/external beam radiotherapy for stage T1-T2 prostate cancer. Int J Radiat Oncol Biol Phy 2004; 58: 25-33.
Tran AT, Mandall P, Swindell R et al. Biochemical outcomes for patients with intermediate risk prostate cancer treated with I-125 interstitial brachytherapy monotherapy. Radiother Oncol 2013; 109: 235-240.
Frank SJ, Levy LB, Van Vulpen M et al. Outcomes after prostate brachytherapy are even better than predicted. Cancer 2012; 118: 839-847.
Jabbari S, Weinberg VK, Shinohara K et al. Equivalent biochemical control and improved prostate-specific antigen nadir after permanent prostate seed implant brachytherapy versus high-dose three-dimensional conformal radiotherapy and high-dose conformal proton beam radiotherapy boost. Int J Radiat Oncol Biol Phys 2010; 76: 36-42.
Kaplan A, German L, Chen J et al. Validation and comparison of the two Kattan nomograms in patients with prostate cancer treated with (125) iodine brachytherapy. BJU Int 2012; 109: 1661-1665.
Zhou P, Chen M-H, McLeod D et al. Predictors of prostate cancer-specific mortality after radical prostatectomy or radiation therapy. J Clin Oncol 2005; 23: 6992-6998.
Kuban D, Thames H, Levy L et al. Failure definition-dependent differences in outcome following radiation for localized prostate cancer: can one size fit all? Int J Radiat Oncol Biol Phys 2005; 61: 409-414.
Ding W, Lee J, Chamberlain D et al. Twelve-month prostate-specific antigen values and perineural invasion as strong independent prognostic variables of long-term biochemical outcome after prostate seed brachytherapy. Int J Radiat Oncol Biol Phys 2012; 84: 962-967.
Morris WJ, Pickles T, Keyes M et al. Pride or prejudice: does Phoenix flatter radiation therapy? Brachytherapy 2014; 13: 299-303.
Pickles T. Prostate-specific antigen (PSA) bounce and other fluctuations: which biochemical relapse definition is least prone to PSA false calls? An analysis of 2030 men treated for prostate cancer with external beam or brachytherapy with or without adjuvant androgen deprivation therapy. Int J Radiat Oncol Biol Phys 2006; 64: 1355-1359.
Caloglu M, Ciezki JP, Reddy C et al. PSA bounce and biochemical failure after brachytherapy for prostate cancer: a study of 820 patients with a minimum of 3 years of follow-up. Int J Radiat Oncol Biol Phys 2011; 80: 735-741.
Ciezki JP, Reddy C, Garcia J et al. PSA kinetics after prostate brachytherapy: PSA bounce phenomenon and its implications for PSA doubling time. Int J Radiat Oncol Biol Phys 2006; 64: 512-517.
Cheung R, Tucker SL, Kuban D. First-year PSA kinetics and minima after prostate cancer radiotherapy are predictive of overall survival. Int J Radiat Oncol Biol Phys 2006; 66: 20-24.
Ray ME, Levy LB, Horwitz EM et al. Nadir prostate-specific antigen within 12 months after radiotherapy predicts biochemical and distant failure. Urology 2006; 68: 1257-1262.
Nag S, Ciezki JP, Cormack R et al. Intraoperative planning and evaluation of permanent prostate brachytherapy: report of the American Brachytherapy Society. Int J Radiat Oncol Biol Phys 2001; 51: 1422-1430.
Beyer DC, Shapiro RH, Puente F. Real-time optimized intraoperative dosimetry for prostate brachytherapy: a pilot study. Int J Radiat Oncol Biol Phys 2000; 48: 1583-1589.
Roach M 3rd, Hanks G, Thames H Jr et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 2006; 65: 965-974.
Critz FA. Time to achieve a prostate specific antigen nadir of 0.2 ng/ml after simultaneous irradiation for prostate cancer. J Urol 2002; 168: 2434-2438.
Thompson A, Keyes M, Pickles T et al. Evaluating the Phoenix definition of biochemical failure after (125)I prostate brachytherapy: Can PSA kinetics distinguish PSA failures from PSA bounces? Int J Radiat Oncol Biol Phys 2010; 78: 415-421.
Caloglu M, Ciezki J. Prostate-specific antigen bounce after prostate brachytherapy: review of a confusing phenomenon. Urology 2009; 74: 1183-1190.
Critz FA, Williams WH, Levinson AK et al. Prostate specific antigen bounce after simultaneous irradiation for prostate cancer: the relationship to patient age. J Urol 2003; 170: 1864-1867.
Lo AC, Morris WJ, Lapointe V et al. Prostate-specific antigen at 4 to 5 years after low-dose-rate prostate brachytherapy is a strong predictor of disease-free survival. Int J Radiat Oncol Biol Phys 2014; 88: 87-93.
Kattan MW, Potters L, Blasko JC et al. Pretreatment nomogram for predicting freedom from recurrence after permanent prostate brachytherapy in prostate cancer. Urology 2001; 58: 393-399.
Kattan MW, Wheeler TM, Scardino PT. Postoperative nomogram for disease recurrence after radical prostatectomy for prostate cancer. J Clin Oncol 1999; 17: 1499-1507.
Keyes M, Macaulay C, Hayes M et al. DNA ploidy measured on archived pretreatment biopsy material may correlate with prostate-specific antigen recurrence after prostate brachytherapy. Int J Radiat Oncol Biol Phys 2013; 86: 829-834.
Oton LF, Dolado MC, Nunez EJ et al. Effect of constipation on dosimetry after permanent seed brachytherapy for prostate cancer. J Contemp Brachytherapy 2015; 7: 247-251.
Wang Y, Nasser NJ, Borg J et al. Evaluation of the dosimetric impact of loss and displacement of seeds in prostate low-dose-rate brachytherapy. J Contemp Brachytherapy 2015; 7: 203-210.
Wallner KE, Blasko J, Dattoli MJ. Prostate brachytherapy made complicated. Smart Medicine Press, Seattle 1997.
Caloglu M, Ciezki JP, Reddy CA et al. PSA bounce and biochemical failure after brachytherapy for prostate cancer: A study of 820 patients with a minimum of 3 years of follow-up. Int J Radiat Oncol Biol Phys 2011; 80: 735-741.
 
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe