eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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SCImago Journal & Country Rank
5/2011
vol. 6
 
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abstract:
Review paper

Pathomechanism of insulin resistance in chronic hepatitis C

Michał Kukla
,
Tomasz Sawczyn
,
Krystyna Żwirska-Korczala
,
Mirosław Jarosz

Przegląd Gastroenterologiczny 2011; 6 (5): 284–289
Online publish date: 2011/11/11
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Chronic hepatitis C (CHC) should be considered not only as viral but also as a metabolic disease. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus, hepatic steatosis, lipid metabolism abnormalities and probably atherosclerosis are the main metabolic manifestations of CHC. The development of IR in CHC seems to be complex, resulting from an ongoing inflammatory process, up-regulation of pro-inflammatory cytokines, fibrosis progression and direct influence of the virus on the insulin signalling pathway. Insulin resistance promotes hepatic steatosis and is associated with fibrosis progression, resistance to antiviral therapy and development of hepatocellular carcinoma. Therefore, understanding the pathogenesis of this phenomenon may by essential to obtain higher efficacy of antiviral therapy and would be helpful in prevention of metabolic disturbances and complications in the course of CHC.
keywords:

insulin resistance, chronic hepatitis C, adipokines, fibrosis, liver

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