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Journal of Contemporary Brachytherapy
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vol. 3

Physics Contributionsons
BiopSee® – transperineal stereotactic navigated prostate biopsy

Pawel Zogal
Georgios Sakas
Woerner Rösch
Dimos Baltas

J Contemp Brachyther 2011; 3, 2: 91-95
Online publish date: 2011/07/06
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Introduction and state of the art

The prostate cancer accounts for 25% of all male cancer occurrences and 9% of the cancer death causes in the European Union. [1]. Only in 2008, it was the most commonly diagnosed type, accounting for 25% of all cancers [2]. In Germany, there are about 58,000 prostate cancer diagnoses each year [3].

As for each cancer type, early diagnosis is extremely important in increasing the treatment effectiveness. Curren­tly, several types of examination are used for screening potential patients: prostate specific antigen (PSA) test, digital rectal examination (DRE) and transrectal ultrasound (TRUS). Those methods however, are not sensitive enough and the only secured diagnosis is the prostate biopsy with following histopathology examination.

At present, the biopsy procedure is done with the help of transrectal 2D ultrasound. The probe is introduced to the patient’s rectum and free-hand navigated by the doctor. The probe is equipped with a needle guide through which a needle is inserted after having established desired probe position towards the prostate area. The first publications in this area recommended a 6 core systematic biopsy [4], but later studies showed that the number was insu­fficient [5, 6]. Currently, the recommendation of the Eu­ropean Urology Association is at least 10 cores, whereas the exact number shall be adjusted according to the PSA level and prostate volume [1].

Because of the fact that early cancer stages are invisible in the ultrasound images, the urologists are forced to take random biopsies without targeting specific cancer areas. This needs a mean of assurance that desired random distribution has been achieved. The biopsy procedure is limited by the 2D imaging, soft consistency and deformability of the prostate and instability of the manual probe navigation. These factors significantly reduce the positioning accuracy and permit a reproducibility of the biopsy needle guidance. The documentation of the biopsy core location is a highly insufficient process.

Thus, the success rate of the standard 12-core TRUS biopsy is ca. 30%. As a result, in around 40% of cases [7-9] a re-biopsy is needed. This happens when the PSA level increases in spite of negative result of the first biopsy. In the second examination, so-called saturation biopsy is performed with 20-40 cores again at random positions. In such circumstance, the doctor ideally has to avoid taking the probes from the places that have been verified earlier as negative. With current standards the information is deficient in order do so. Today, one tries to compensate the inaccuracy by an increased number of following cores, which in fact, increases patient’s burden as well.

Alternative approaches like MRI-based techniques are developing fast and are truly promising [2], but they are much more expensive in comparison to an ultrasound and severely more time and resources consuming in terms of time pro biopsy core taken.

Advances by the presented contribution

Recent developments in morphologic, metabolic and physiologic 3D imaging – typically MRI-based – are showing very good prospects for tumour localization within the prostate. Unfortunately, those technologies are expensive (about 2-3 million € investment for a single site needed) and their real-time capability is very restricted. Further, they provide a good localisation of suspicious lesions, however give no guidance to stereotactical biopsy of these loca­tions. To overcome these problems and increase biopsy success rate, we introduced a device combining every usable imaging information along with real-time ultrasound. The general idea is to use imaging to localize areas suspected of cancer and ultrasound to guide biopsy needles precisely to exactly those areas.

In our approach the user can fuse intraoperatively acquired 3D ultrasound on one hand with preoperatively acquired modalities, such as multi-parametric MRI, PET, SPECT or any other 3D dataset available in DICOM format to denote suspicious lesions and plan a targeted biopsy. The usage of the digital integrated ultrasound greatly improves 2D and 3D image quality. The real-time augmented reality ultrasound guidance improves greatly biopsy accuracy and reduces navigation time. The system also provides means for the procedure documentation which is essential in follow-up examinations and some novel treatment methods like brachytherapy and focal therapy of the prostate [10]. Additionally, by using the transperineal approach one reaches every prostate area, minimizes deformation, maximises reproducibility and reduces the risk of infection associated with bacteria from the rectum infiltrating the prostate during the rectal insertion process [11]. A summary of the risks present during the conventional transrectal biopsy can be found in [12].

Material and methods

System architecture

The presented device consists of a cart with a touch-screen and a PC with integrated ultrasound device and additional electronics for controlling position and orientation of the ultrasound probe. The probe itself is a custom bi-plane endorectal design that is optimized for biopsy process: longer shaft optimized mechanical design, 165° transversal and 75 mm longitudinal field of view. Each of the arrays consists of 128 elements, the maximum available frequency is 8 MHz for the transversal plane and 10 MHz for the longitudinal one. This accounts for delivering superb quality images, which are also additionally filtered by the software. The result is U/S images with de facto the best diagnostic quality available today.

During the procedure, the probe is placed in a mechanical custom-made fixation device called the stepper. This is a 2DoF set up: one can adjust probe depth within the patient’s rectum and the rotation of the probe along its main axis. Both movement and rotation are tracked by 2 encoders which are connected to the aforementioned electronics inside the PC. The movement resolution is 0.1 mm and 0.1° for the rotation, respectively. The stepper itself is fixed to the operation table. As a result, one can image any plane of the prostate with very high accuracy and reproducibility, a fact impossible in the free-hand movement of the probe.

For the needle insertion part we developed a dedicated movable needle guide that is attached to the stepper. It has adjustable X and Y coordinates enabling to drive a needle with mm accuracy to any location within the prostate. The whole hardware set up is principally similar to the one used in a brachytherapy procedure, which gives the advan­tage that one could reuse certain equipment in both diagnosis and therapy. However, our new positioning device allows among others to pinpoint any position within the prostate without gridding truncations. However, the software supports also any kind of templates like those usually employed in brachytherapy procedures.

On the software side, the system design is modular. There is a kernel environment and each functional procedure step is mapped within a separate software module. Those inclu­de: ultrasound device control, U/S image filtering, stepper encoder control, U/S data acquisition, DICOM data interface, volume fusion, contouring, biopsy planning, guiding, reporting and the dedicated patient database.


The user is free to perform different actions within the system, though a typical workflow for the navigated biopsy can be recommended and presented here. The procedure can be split into planning the biopsy and guided removal of the tissue cores.

In the first phase image, the data is acquired and respective organs and regions are delineated and marked. One can import different DICOM image modalities and fuse them with on-board 3D ultrasound. 3D U/S is acquired by recording a series of transversal or longitudinal 2D images while rotating or moving the probe along the Z direction, resulting very similar dataset to CT scans, however generated with ultrasound instead of X-rays. Additional imaging modalities, typically multiparametric MRI are imported through the DICOM interfaces. Both 3D volumes are then fused together using one of many available methods: manual, marker based or automatic [13]. This allows tran­sferring organ and lesions usually visible on the diagnostic MRI scan and delineated by a radiologist over the intra­operative ultrasound dataset.

Finally, biopsy cores are placed virtually within the 3D data manually or automatically according to a pre-defined protocol. The experience shows that doctors use predo­minantly a combination of stereotactic target based and statistical biopsy. Once a biopsy plan has been established, the first phase of the approach is completed typically within 10-15 minutes.

During the following second (navigation) phase the user selects the desired biopsy core and first navigates the ultra­sound probe to that position, i.e. the U/S transducer rotates until the longitudinal plane crosses the needle inser­tion line. Next, the needle guide template is set to the planned coordinates by adjusting the X and Y coordinates by the values given by the planning tool. Last, the physician inserts the needle under continuous longitudinal ultrasound guidance.

The U/S image is overlaid by the organ and lesion contours as well as the planned needle position, thus a real-time navigation is established in a way that deviations from the target become immediately visible on the screen and can be corrected on-the-fly, enabling a positioning of the needle by very high accuracy of few mm from the desired target position. Organ shifts caused by the tissue deformation during needle insertion are equally visible and can be adjusted manually if necessary. After each needle insertion, a screenshots is made and stored together with the position and orientation data for documentation purposes.


Documenting the procedure is an essential feature for follow-up examinations and treatment. The presented system has a custom designed patient database which allows saving any type of data used within the procedure. Our approach is the only one enabling complete and automatic documentation of the procedure without any user interaction. All information (images, contours, targets etc.) can be exported via DICOM-RT protocol to the therapy RTP system.


During the biopsy procedure one can mark the real needle position on the live ultrasound image. In order to measure the positioning accuracy, reconstructed needles are stored and their positions and compared to the planned ones. The preliminary assessment was comparing the distances between middle points of reconstructed biopsy cores and the planned ones. Within a dataset of 1159 needles reconstructed during the first 50 biopsy procedures, the calculated mean error was 1.7 mm. With conventional transrectal biopsy such assessment is not possible.

Results with the first 50 patients (submitted for publication) have been performed for a typical cohort (PSA 9 ± 7, prostate 51 ± 24 cm3, age 42-77). A saturation biopsy with an average of 24 cores was performed. In addition to the random cores, stereotactic samples have been taken from MRI suspicious areas. Cancer could be detected in 68% of the cases of first-time biopsies and 36% of re-biopsy after 1-3 initial negative 12-core TRUS biopsies. The average time for the procedure was 25 minutes.

In addition to the high detection rates, the principal benefit of our approach is its accuracy and reproducibility. Accuracy is needed for validating the MRI findings and, thus, the MRI method itself. Reproducibility means that since we track the needle location within the prostate accurately and we can reach effectively any prostate region, the biopsy cores are obtained guaranteed from different regions and by a regular scheme ensuring correct statistic coverage of the complete organ. This is important in the case of repeated biopsy procedure: new cores can be taken from areas where no needle has been placed in the first procedure. Also, our method is of fundamental importance for focal therapy approaches in excluding multi-focal or non-visible lesions on the opposite prostate gland.


We presented a novel system for navigated prostate biopsy, which takes advantage of several computer graphics methods to enhance the examination procedure. The image fusion along with different visualization modes enables easier organ and target lesion delineation and thus effective biopsy planning and exact and reproducible core samples under automatic documentation. Our experience shows that the needle and probe navigation feature together with combining live ultrasound imaging with virtual objects is essential for accurate and reproducible needle insertion. The system has been clinically tested at the Offenbach Clinic and at the Heidelberg University Hospital. Tests in both hospitals with over hundred of patients confirmed the advantages of the image guided stereotactic prostate biopsy [14]. The implemented DICOM RT protocol for transferring the biopsy cores localisation, enables treatment planning systems to consider these locations for local dose escalation protocols (dose painting).


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Copyright: © 2011 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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