eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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vol. 29
Review paper

Premature pubarche during minipuberty – literature review and two case reports

Anna Rakuś-Kwiatosz
1, 2
Elżbieta Budzyńska
Iwona Beń-Skowronek

Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Poland
Department of Pediatric Propedeutics, Medical University of Lublin, Poland
Pediatr Endocrinol Diabetes Metab 2023; 29 (2): 112-117
Online publish date: 2023/07/15
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Isolated premature pubarche (PP) in infancy may be the reason for many diagnostic difficulties. This is due to the low incidence and, therefore, the limited number of studies on this subject and the lack of strict laboratory standards because of the physiological variability of gonadotropic hormone and androgen concentrations during minipuberty.

Material and methods
We aimed to present current knowledge about PP in infancy based on the literature review and 2 cases of male infants with scrotal hair during minipuberty.

Isolated hair in the pubic region in a boy during the period of minipuberty requires differential diagnosis. After excluding serious aetiology, it seems to be a mild, self-limiting variant of precocious puberty. The phenomenon is probably a result of increased sensitivity of the hair follicles to transiently increased androgen concentration.

Isolated pubic hair in infancy as a mild, self-limiting variant of precocious puberty in infants should be a diagnosis of exclusion. The condition resolves spontaneously, but it absolutely requires further follow-up to exclude serious aetiology in the case of puberty progression.


infancy, precocious puberty, pubic hair, minipuberty, premature pubarche

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