Preoperative oxidative stress as a biomarker of postoperative complications in colorectal cancer patients

Konrad Zaręba; Justyna Dorf; Kerianne M. Cummings; Mateusz Maciejczyk; Anna Zalewska; Bogusław Kędra

doi:10.5114/pg.2025.156811

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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4/2025
vol. 20

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abstract:

Original paper

Preoperative oxidative stress as a biomarker of postoperative complications in colorectal cancer patients

Konrad Zaręba

¹

,

Justyna Dorf

²

,

Kerianne M. Cummings

³

,

Mateusz Maciejczyk

⁴

,

Anna Zalewska

⁵

,

Bogusław Kędra

⁶

Department of Oncological Surgery and General Surgery, Marian Zyndram-Kościałkowski Public Health Care Center of the Ministry of the Interior and Administration, Bialystok, Poland
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland
Students’ Scientific Association, 2nd Clinical Department of General, Gastroenterological and Oncological Surgery, Medical University of Bialystok, Poland
Department of Hygiene and Epidemiology, Medical University of Bialystok, Poland
Independent Laboratory of Experimental Dentistry, Medical University of Bialystok, Poland
2nd Clinical Department of General, Gastroenterological and Oncological Surgery, Medical University of Bialystok, Poland

Gastroenterology Rev 2025; 20 (4): 409–423

DOI: https://doi.org/10.5114/pg.2025.156811

Online publish date: 2025/12/07

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Introduction
Relationships between redox homeostasis, nutritional status, and postoperative complications in patients with colorectal cancer are still unexplained.

Aim
This study aimed to evaluate selected parameters of oxidative stress and nutritional status in colorectal cancer patients and their impact on postoperative complications.

Material and methods
The study included 50 patients with colorectal cancer. In all patients, body mass index (BMI), body weight loss, and the Nutritional Risk Screening tool (NRS 2002) were assessed. The levels of total protein and albumin, complete blood count (CBC), total antioxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) level were measured. Oxidative stress index (OSI) and the TAC/MDA ratio were calculated.

Results
We detected a significantly higher TAC level (p = 0.0017) and lower TOS level in patients with normal BMI compared to those with increased BMI. We observed a higher TAC level in patients without weight loss (p = 0.0407), whereas the MDA concentration was higher in patients with weight loss than in those without weight loss (p = 0.0025). TAC was significantly higher whereas TOS, OSI, and TAC/MDA ratio were significantly lower in patients without symptoms of malnutrition (p < 0.05). Patients without postoperative complications had higher levels of TOS and MDA, and a lower level of TAC (p < 0.05).

Conclusions
The occurrence of postoperative complications may be associated with increased oxidative stress in patients with colorectal cancer.

keywords:

Preoperative oxidative stress as a biomarker of postoperative complications in colorectal cancer patients

Konrad Zaręba 1 , Justyna Dorf 2 , Kerianne M. Cummings 3 , Mateusz Maciejczyk 4 , Anna Zalewska 5 , Bogusław Kędra 6

colorectal cancer, oxidative stress, body mass index, nutrition, postoperative complications

Konrad Zaręba

¹

,

Justyna Dorf

²

,

Kerianne M. Cummings

³

,

Mateusz Maciejczyk

⁴

,

Anna Zalewska

⁵

,

Bogusław Kędra

⁶