Primary biliary cirrhosis – etiopathogenetic dilemmas

Krzysztof Gutkowski; Marek Hartleb

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

3/2008
vol. 3

Send email

Copy url:

abstract:

Primary biliary cirrhosis – etiopathogenetic dilemmas

Krzysztof Gutkowski

,

Marek Hartleb

Przegląd Gastroenterologiczny 2008; 3 (3): 125–130

Online publish date: 2008/06/09

View full text Get citation

Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by an autoreactive T-lymphocyte mediated injury of interlobular bile ducts. However, the pathogenesis of this disease is not completely understood. In the light of current knowledge the development of PBC seems to be a result of environmental or genetic factors. Primary bile duct injury may be caused by infective, chemical or toxic factors. In genetically susceptible individuals this injury may lead to a T-cell mediated autoimmune response directed against bile duct epithelial cells. When immune mediated bile duct injury has been initiated, the disease leads to chronic cholestasis, fibrosis and hepatic cirrhosis. In this paper we discuss recent views on etiopathogenesis of PBC.

keywords:

Primary biliary cirrhosis – etiopathogenetic dilemmas

Krzysztof Gutkowski , Marek Hartleb

primary biliary cirrhosis, etiopathogenesis, molecular mimicry, autoimmunization

Krzysztof Gutkowski

,

Marek Hartleb