eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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SCImago Journal & Country Rank
2/2020
vol. 45
 
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abstract:
Clinical immunology

Proinflammatory cytokine polarization in type 2 diabetes

Mervat M. Bahgat
1
,
Dalia R. Ibrahim
1

1.
Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt
Cent Eur J Immunol 2020; 45 (2): 170-175
Online publish date: 2020/07/27
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Subclinical inflammatory reaction is associated with non-insulin dependent diabetes. Therefore, the aim of the present study is to describe the effect of the three cytokines: interferon g (IFN-g), interleukin (IL)-4 and IL-5 on the development of type 2 diabetes (T2D). Forty-five volunteers (after their permission) were participated in this work; according to their clinical examination and laboratory investigations (fasting blood sugar, 2 hours postprandial, HbA1c and lipid profile), they were divided into thirteen control (non-diabetic) (five females and eight males) and thirty-two diabetic patients (twenty-one females and eleven males). Thereafter, their sera were evaluated for C-reactive protein (CRP), IFN-g, IL-4 and IL-5. The results revealed an increasing trend of CRP and a significant increase of IFN-g in diabetic patients with no sex difference. A positive correlation between IFN-g and both IL-4 and IL-5 in control, and a positive correlation between IL-4 and IL-5 in diabetic patients had been visualized. These results denoted that there may be an association of the pro-inflammatory cytokines in the etiology of diabetes mellitus type 2.
keywords:

cytokines, proinflammatory, type 2 diabetes, interleukin 4, interferon g, interleukin 5

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