eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 28

Relationship between IL-8, IL-10, MMP-9 level and morphological pattern of BAL fluid

Beata Białas-Chromiec
Dorota Magdalena Radomska-Leśniewska
Ewa Skopińska-Różewska
Jan Kuś
Joanna Chorostowska-Wynimko
Małgorzata Sobiecka
Stefan Wesołowski

Centr Eur J Immunol 2003; 28 (4): 155-159
Online publish date: 2004/09/17
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There is an increasing evidence that imbalance between pro- and anti-inflammatory factors such as cytokines and proteases is able to direct course of inflammatory lung diseases. Possible relations between proinflammatory interleukin (IL) - 8 and proangiogenic metalloproteinase-9 (MMP-9) as well as antiinflammatory interleukin-10 in bronchoalveolar lavage fluid (BALf) of pulmonary sarcoidosis (BBS) (n=18), idiopathic pulmonary fibrosis (IPF) (n=10) and hypersensitivity pneumonitis (HP) (n=9) patients were examined. IL-8, IL-10 and MMP-9 concentrations in BAL supernatants were determined using ELISA test. A strong correlation (p<0.01) between concentration of IL-8 and MMP-9 in BALf of studied groups was found. Moreover, in IPF group the level of MMP-9 strongly correlated (p<0.01) with IL-10 as well as negatively with relative count of macrophages (p<0.05); while the relative count of neutrophils positively correlated with IL-10 (p<0.01) as well as MMP-9 (p<0.01). In BBS stage I group negative correlation between level of IL-10 and macrophages relative count (p<0.05) as well as positive correlation between IL-10 and lymphocytes relative count (p<0.05) was present. Activity of MMPs and their close relationship with proinflammatory and antiinflammatory factors such IL-8 and IL-10 suggest the contribution of angiogenesis in pathogenesis of interstitial lung disease. Further studies should reveal more data concerning the possible therapeutic approach involving both antiinflammatory and antiangiogenic activities.

interstitial lung diseases, interleukin-8, interleukin-10, metalloproteinase-9, angiogenesis, bronchoalveolar lavage fluid

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