eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2003
vol. 28
 
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abstract:

Relationship between IL-8, IL-10, MMP-9 level and morphological pattern of BAL fluid

Beata Białas-Chromiec
,
Dorota Magdalena Radomska-Leśniewska
,
Ewa Skopińska-Różewska
,
Jan Kuś
,
Joanna Chorostowska-Wynimko
,
Małgorzata Sobiecka
,
Stefan Wesołowski

Centr Eur J Immunol 2003; 28 (4): 155-159
Online publish date: 2004/09/17
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There is an increasing evidence that imbalance between pro- and anti-inflammatory factors such as cytokines and proteases is able to direct course of inflammatory lung diseases. Possible relations between proinflammatory interleukin (IL) - 8 and proangiogenic metalloproteinase-9 (MMP-9) as well as antiinflammatory interleukin-10 in bronchoalveolar lavage fluid (BALf) of pulmonary sarcoidosis (BBS) (n=18), idiopathic pulmonary fibrosis (IPF) (n=10) and hypersensitivity pneumonitis (HP) (n=9) patients were examined. IL-8, IL-10 and MMP-9 concentrations in BAL supernatants were determined using ELISA test. A strong correlation (p<0.01) between concentration of IL-8 and MMP-9 in BALf of studied groups was found. Moreover, in IPF group the level of MMP-9 strongly correlated (p<0.01) with IL-10 as well as negatively with relative count of macrophages (p<0.05); while the relative count of neutrophils positively correlated with IL-10 (p<0.01) as well as MMP-9 (p<0.01). In BBS stage I group negative correlation between level of IL-10 and macrophages relative count (p<0.05) as well as positive correlation between IL-10 and lymphocytes relative count (p<0.05) was present. Activity of MMPs and their close relationship with proinflammatory and antiinflammatory factors such IL-8 and IL-10 suggest the contribution of angiogenesis in pathogenesis of interstitial lung disease. Further studies should reveal more data concerning the possible therapeutic approach involving both antiinflammatory and antiangiogenic activities.
keywords:

interstitial lung diseases, interleukin-8, interleukin-10, metalloproteinase-9, angiogenesis, bronchoalveolar lavage fluid

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