Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways

Robert Zdanowski; Małgorzata Krzyżowska; Dominika Ujazdowska; Aneta Lewicka; Sławomir Lewicki

doi:10.5114/ceji.2015.54602

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2015
vol. 40

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abstract:

Review paper

Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways

Robert Zdanowski

,

Małgorzata Krzyżowska

,

Dominika Ujazdowska

,

Aneta Lewicka

,

Sławomir Lewicki

(Cent Eur J Immunol 2015; 40 (3): 373-379)

DOI: https://doi.org/10.5114/ceji.2015.54602

Online publish date: 2015/10/15

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Acetylcholine has been well known as one of the most exemplary neurotransmitters. In humans, this versatile molecule and its synthesizing enzyme, choline acetyltransferase, have been found in various non-neural tissues such as the epithelium, endothelium, mesothelium muscle, blood cells and immune cells. The non-neuronal acetylcholine is accompanied by the expression of acetylcholinesterase and nicotinic/muscarinic acetylcholine receptors. Increasing evidence of the non-neuronal acetylcholine system found throughout the last few years has indicated this neurotransmitter as one of the major cellular signaling molecules (associated e.g. with kinases and transcription factors activity). This system is responsible for maintenance and optimization of the cellular function, such as proliferation, differentiation, adhesion, migration, intercellular contact and apoptosis. Additionally, it controls proper activity of immune cells and affects differentiation, antigen presentation or cytokine production (both pro- and anti-inflammatory). The present article reviews recent findings about the non-neuronal cholinergic system in the field of immune system and intracellular signaling pathways.

keywords:

Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways

Robert Zdanowski , Małgorzata Krzyżowska , Dominika Ujazdowska , Aneta Lewicka , Sławomir Lewicki

α7 nicotinic receptor, immune system, intracellular signaling pathways

Robert Zdanowski

,

Małgorzata Krzyżowska

,

Dominika Ujazdowska

,

Aneta Lewicka

,

Sławomir Lewicki