Same Skin, Different Story: Exploring the Clinical Spectrum
of Hypomelanosis of Ito in Two Paediatric Patients

Martyna Duda; Hubert Arasiewicz; Michał Dec

doi:10.5114/dr.2025.160175

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Zeszyty specjalne Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Standardy etyczne i procedury

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Otwarty dostęp

6/2025
vol. 112

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Opis przypadku

Same Skin, Different Story: Exploring the Clinical Spectrum of Hypomelanosis of Ito in Two Paediatric Patients

Martyna K. Duda

¹

,

Hubert Arasiewicz

¹

,

Michał Dec

¹

Clinical Department of Pediatric Dermatology and Vascular Anomalies, Faculty of Medical Sciences in Katowice, Medical University of Silesia, John Paul II Children’s and Family Health Center, Sosnowiec, Poland

Dermatol Rev/Przegl Dermatol 2025, 112, 368-372

DOI: https://doi.org/10.5114/dr.2025.160175

Data publikacji online: 2026/02/28

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Metryki PlumX:

Introduction
Hypomelanosis of Ito is a cutaneous mosaic disorder characterized by hypopigmented lesions along the lines of Blaschko. It may present as an isolated skin finding or be associated with multisystem abnormalities, classifying it as a neurocutaneous syndrome.

Objective
To present two paediatric cases of hypopigmentation distributed along the lines of Blaschko – one associated with multisystem involvement and the other limited to cutaneous findings.

Case report
The first case involved a 5-year-old boy with pigmentary mosaicism and multiple extracutaneous features, including developmental delay, chest wall deformity, and auditory and ophthalmologic anomalies, consistent with hypomelanosis of Ito. The second case, a 9-year-old boy, had similar cutaneous findings but no systemic involvement, consistent with cutaneous pigmentary mosaicism.

Conclusions
These cases highlight the spectrum of hypomelanosis of Ito and the importance of a thorough clinical evaluation. Recognizing extracutaneous manifestations is key to accurate diagnosis, appropriate follow-up, and interdisciplinary care.

Indeks osobowy

Same Skin, Different Story: Exploring the Clinical Spectrum of Hypomelanosis of Ito in Two Paediatric Patients

Martyna K. Duda 1 , Hubert Arasiewicz 1 , Michał Dec 1

Martyna K. Duda

¹

,

Hubert Arasiewicz

¹

,

Michał Dec

¹