eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2018
vol. 43
 
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abstract:
Clinical immunology

Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis

Małgorzata Mizerska-Wasiak, Łukasz Gajewski, Karolina Cichoń-Kawa, Jadwiga Małdyk, Katarzyna Dziedzic-Jankowska, Beata Leszczyńska, Agnieszka Rybi-Szumińska, Anna Wasilewska, Agnieszka Pukajło-Marczyk, Danuta Zwolińska, Beata Bieniaś, Przemysław Sikora, Maria Szczepańska, Anna Stelmaszczyk-Emmel, Elżbieta Górska, Małgorzata Pańczyk-Tomaszewska

(Centr Eur Immunol 2018; 43 (2): 162-167)
Online publish date: 2018/06/30
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Introduction
GDIgA1 (galactose deficient IgA1) plays a significant role in the pathogenesis of IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSN)

Aim and study
The aim of this study was to assess the relevance of serum GDIgA1 level as a prognostic marker in children with IgAN and HSN.

Material and Methods
41 children were included to the study group (15 IgAN, 26 HSN) and 22 to the control group. The following parameters were evaluated at baseline and endpoint: proteinuria, erythrocyturia, serum creatinine, serum IgA, GFR. A kidney biopsy was performed in all patients and evaluated according to the Oxford Classification (1 – present, 0 – absent: M – mesangial hypercellularity; E– endocapillary hypercellularity; S – segmental sclerosis/adhesion; T – tubular atrophy/interstitial fibrosis), and was calculated as the total score (sum of M, E, S, T). At the end of follow-up, the serum GDIgA1 concentration was measured.

Results
The serum GDIgA1 concentration in patients with IgAN and HSN was significantly higher than in the control group. No significant differences in mean proteinuria, erythrocyturia, GFR, MEST score, or GDIgA1 in serum, as well as the duration of follow-up between IgAN and HSN were observed. Baseline serum IgA concentration and time to kidney biopsy were significantly higher in children with IgAN than in children with HSN. We observed a positive correlation between GDIgA1 and IgA levels (r = 0.53), and GDIgA1 and serum creatinine levels (r = 0.5), as well as negative correlation between GDIgA1 and GFR (r = –0.37).

Conclusions
Serum GDIgA1 level may have a prognostic value in children with IgAN and HSN; however, to fully elucidate its clinical potential further studies performed in larger patient cohorts are required.

keywords:

galactose deficient IgA1, IgAN, HSN, children

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