eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2021
vol. 46
 
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abstract:
Clinical immunology

Shared epitope and polymorphism of MICA and NKG2D encoding genes in Greek and Polish patients with rheumatoid arthritis

Joanna Wielińska
1
,
Katerina Tarassi
2
,
Milena Iwaszko
1
,
Katarzyna Kościńska
3
,
Barbara Wysoczańska
1
,
Evangelia Mole
4
,
Vasiliki Kitsiou
2
,
Jerzy Świerkot
5
,
Katarzyna Kolossa
6
,
Diamanto Kouniaki
2
,
Theofilos Athanassiades
2
,
Alexandra Tsirogianni
2
,
Katarzyna Bogunia-Kubik
1

1.
Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
2.
Immunology-Histocompatibility Department, Evangelismos Hospital, Athens, Greece
3.
Lower Silesian Center for Cellular Transplantation, Wrocław, Poland
4.
Rheumatology Department, Evangelismos Hospital, Athens, Greece
5.
Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Wrocław, Poland
6.
Clinical Department of Rheumatology and Connective Tissue Diseases, Jan Biziel University Hospital No. 2, Bydgoszcz, Poland
Cent Eur J Immunol 2021; 46 (1): 92-98
Online publish date: 2021/03/15
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The present study aimed to analyse and compare the distribution of MICA (rs1051792) and NKG2D/KLRK1 (rs1154831, rs1049174, rs2255336) polymorphisms in 61 Greek and 100 Polish patients with rheumatoid arthritis in relation to the presence of the HLA-DRB1 shared epitope and clinical parameters. Genotyping of selected polymorphism was performed using real-time PCR. HLA-DRB1 shared epitope alleles segregated differently in Greek and Polish patients but in both populations were detected in over 60% of cases. The rs1051792-A variant was more common among SE-positive Polish patients (p = 0.003) while the rs1049174-G allele was more frequently observed in Greeks than in Poles (p < 0.001). Moreover, among Greek patients, the rs1051792-GG homozygotes more frequently presented with anti-CCP antibodies and rheumatoid factor (RF), while carriers of the rs1049174-G variant and rs1154831-CC homozygotes were characterized by lower disease activity scores (p < 0.05 in all cases). These results imply that, in addition to the HLA-DRB1 SE alleles, MICA and NKG2D polymorphisms may also play a role in rheumatoid arthritis.
keywords:

HLA-DRB1 shared epitope, NKG2D, MICA, polymorphism, rheumatoid arthritis

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