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Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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Original paper

The impact of apelin on polarization of macrophages in the microenvironment of colon cancer

Fatma Seçer-Çelik
1
,
Canan Eroğlu-Güneş
2
,
Emine Yavuz
3
,
Ercan Kurar
2

  1. Ankara Medipol University, Turkey
  2. Necmettin Erbakan University, Turkey
  3. Selçuk University, Turkey
Cent Eur J Immunol 2025; 50 (2)
Online publish date: 2025/06/02
Article file
- The impact of apelin.pdf  [0.89 MB]
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1. West NR, McCuaig S, Franchini F, Powrie F (2015): Emerging cytokine networks in colorectal cancer. Nat Rev Immunol 15: 615-629.
2. Lasry A, Zinger A, Ben-Neriah Y (2016): Inflammatory networks underlying colorectal cancer. Nat Immunol 17: 230-240.
3. Jochem C, Leitzmann M (2016): Obesity and colorectal cancer. Recent Results Cancer Res 208: 17-41.
4. Kadowaki T, Yamauchi T (2005): Adiponectin and adiponectin receptors. Endocr Rev 26: 439-451.
5. Carpéné C, Dray C, Attané C, et al. (2007): Expanding role for the apelin/APJ system in physiopathology. J Physiol Biochem 63: 359-373.
6. Boucher J, Masri B, Daviaud D, et al. (2005): Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146: 1764-1771.
7. Wysocka MB, Pietraszek-Gremplewicz K, Nowak D (2018): The role of apelin in cardiovascular diseases, obesity and cancer. Front Physiol 9: 557-566.
8. Lin ZY, Chuang WL (2013): Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts. Kaohsiung J Med Sci 29: 312-318.
9. Lv D, Li L, Lu Q, et al. (2016): PAK1-cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin-13. Clin Exp Pharmacol Physiol 43: 569-579.
10. Picault FX, Chaves Almagro C, Projetti F, et al. (2014): Tumour co expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas. Eur J Cancer 50: 663 674.
11. Altinkaya SO, Nergiz S, Küçük M, Yüksel H (2015): Apelin levels are higher in obese patients with endometrial cancer. J Obstet Gynaecol Res 41: 294-300.
12. Unal I, Khiavi IR, Tasar GE, et al. (2020): Tumor apelin immunoreactivity is correlated with body mass index in ovarian high grade serous carcinoma. Biotech Histochem 95: 27-36.
13. Çelik FS, Güneş CE, Yavuz E, Kurar E (2023): Apelin triggers macrophage polarization to M2 type in head and neck cancer. Immunobiology 228: 152353.
14. Kawai T, Akira S (2010): The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
15. Salmaninejad A, Valilou SF, Soltani A, et al. (2019): Tumor-associated macrophages: role in cancer development and therapeutic implications. Cell Oncol 42: 591-608.
16. Podgórska M, Diakowska D, Pietraszek Gremplewicz K, et al. (2019): Evaluation of apelin and apelin receptor level in the primary tumor and serum of colorectal cancer patients. J Clin Med 8: 1513.
17. Xin Q, Cheng B, Pan Y, et al. (2015): Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation. Peptides 63: 55-62.
18. Cui J, Ren Z, Zou W, Jiang Y (2017): miR-497 accelerates oxidized low-density lipoprotein-induced lipid accumulation in macrophages by repressing the expression of apelin. Cell Biol Int 41: 1012-1019.
19. Massague J (2012): TGFb signaling in context. Nat Rev Mol Cell Biol 13: 616-630.
20. Cao W, Peters JH, Nieman D, et al. (2015): Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro. Br J Cancer 113: 738-746.
21. Barbera-Guillem E, Nyhus JK, Wolford CC, et al. (2022): Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process. Cancer Res 62: 7042-7049.
22. Qian BZ, Li J, Zhang H, et al. (2011): CCL2 recruits inflammatory monocytes to facilitate breast- tumour metastasis. Nature 475: 222-225.
23. Allavena P, Chieppa M, Monti P, Piemonti L (2004): From pattern recognition receptor to regulator of homeostasis: the double-faced macrophage mannose receptor. Crit Rev Immunol 24: 179-192.
24. Saiki H, Hayashi Y, Yoshii S, et al. (2023): The apelin apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells. Int J Oncol 63: 139.
Copyright: © 2025 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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