eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 45
Review paper

The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases

Karolina Kaźmierczak-Siedlecka
Agnieszka Daca
Marcin Folwarski
Jacek M. Witkowski
Ewa Bryl
Wojciech Makarewicz

  1. Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland
  2. Department of Pathology and Experimental Rheumatology, Medical University of Gdansk, Gdansk, Poland
  3. Department of Clinical Nutrition and Dietetics, Medical University of Gdansk, Gdansk, Poland
  4. Department of Physiopathology, Medical University of Gdansk, Gdansk, Poland
Centr Eur J Immunol 2019; 45 (4): 488-493
Online publish date: 2021/01/25
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Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

Lactobacillus plantarum 299v, cancer, Clostridium difficile infection, irritable bowel syndrome, diarrhea

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