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Journal of Contemporary Brachytherapy
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Interview with Professor Janusz Skowronek
ABS 2015
2/2017
vol. 9
 
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abstract:
Original paper

The use of trans-applicator intracavitary ultrasonography in brachytherapy for cervical cancer: phantom study of a novel approach to 3D image-guided brachytherapy

Tomoaki Tamaki, Kazunori Miyaura, Toshihiro Murakami, Yu Kumazaki, Yoshiyuki Suzuki, Takashi Nakano, Shingo Kato

J Contemp Brachytherapy 2017; 9, 2: 151–157
Online publish date: 2017/03/15
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Purpose: To assess the feasibility of applying trans-applicator intracavitary ultrasonography to image-guided brachytherapy for cervical cancer.

Material and methods: For this experiment, a phantom was created and included a polyethylene tube, intended to simulate a tandem applicator, which was inserted into chicken meat and embedded in agar, along with magnetic reso­nance imaging (MRI)-compatible ovoid applicators. Three-dimensional images of the phantom were obtained using computed tomography (CT), MRI (T2-weighted), and intracavitary ultrasonography sectional images acquired at 1 mm slice intervals. Intracavitary ultrasonography images were acquired from within the simulated tandem applicator using a radial transducer. Magnetic resonance imaging and intracavitary ultrasonography images were manually registered onto CT images. The chicken meat was contoured as the target volume independently on the CT, MRI, and intracavitary ultrasonography images, and the Dice similarity coefficient was used to compare the target volumes. The dose distributions of a sample brachytherapy plan were also evaluated.

Results: Computed tomography, MRI, and intracavitary ultrasonography all visualized the three-dimensional phantom volumes. Intracavitary ultrasonography images depicted the meat with high echoic signals and a border clearly distinguishable from the surrounding agar. The Dice similarity coefficient values for the target volumes on CT vs. MRI, CT vs. intracavitary ultrasonography, and MRI vs. intracavitary ultrasonography were 0.966, 0.965, and 0.971, respectively, indicating similar contouring with the three modalities. Among the modalities, the differences in D50, D90, D98, and D100 values were 1.8%, 2.9%, 3.7%, and 2.9%, respectively.

Conclusions: Three-dimensional reconstructed trans-applicator intracavitary ultrasonographic images clearly depicted meat tissue within the phantom, and could thus be used for brachytherapy planning. This study proves the concept of trans-applicator intracavitary ultrasonography for intracavitary brachytherapy. Further research such as development of intracavitary ultrasonography system, 3D reconstruction method, ultrasonography-compatible applicators, and ultrasonography-based target concept is warranted to assess the potential clinical application.
keywords:

brachytherapy, cervical cancer, intracavitary ultrasonography

references:
Pötter R, Kirisits C, Fidarova EF et al. Present status and future of high-precision image guided adaptive brachytherapy for cervix carcinoma. Acta Oncol 2008; 47:1325-1336.
Viswanathan AN, Erickson BA. Seeing is saving: the benefit of 3D imaging in gynecologic brachytherapy. Gynecol Oncol 2015; 138: 207-215.
Pötter R, Georg P, Dimopoulos JC et al. Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer. Radiother Oncol 2011; 100:116-123.
Simpson DR, Scanderbeg DJ, Carmona R et al. Clinical outcomes of computed tomography-based volumetric bra­chy­therapy planning for cervical cancer. Int J Radiat Oncol Biol Phys 2015; 93: 150-157.
Georg P, Pötter R, Georg D et al. Dose effect relationship for late side effects of the rectum and urinary bladder in magnetic resonance image-guided adaptive cervix cancer bra­chy­therapy. Int J Radiat Oncol Biol Phys 2012; 82: 653-657.
Kato S, Tran DN, Ohno T et al. CT-based 3D dose-volume parameter of the rectum and late rectal complication in patients with cervical cancer treated with high-dose-rate intracavitary brachytherapy. J Radiat Res 2010; 51: 215-221.
Mazeron R, Fokdal LU, Kirchhener K et al. Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study. Radiother Oncol 2016; 120: 412-419.
Denny L, Herrero R, Levin C et al. Cervical Cancer. In: Cancer: Disease Control Priorities. Gelband H, Jha P, Sankaranarayanan R, Horton S (eds.). 3rd ed. Volume 3. The International Bank for Reconstruction and Development/The World Bank, Washington 2015; Chapter 4.
Kim H, Rajagopalan MS, Beriwal S et al. Cost-effectiveness analysis of 3D image-guided brachytherapy compared with 2D brachytherapy in the treatment of locally advanced cervical cancer. Brachytherapy 2015; 14: 29-36.
Davis BJ, Horwitz EM, Lee R et al. American Brachytherapy Society consensus guidelines for transrectal ultrasound-guided permanent prostate brachytherapy. Brachytherapy 2012; 11: 6-19.
Hoskin PJ, Colombo A, Henry A et al. GEC/ ESTRO recommendations on high dose rate afterloading brachytherapy for localized prostate cancer: An update. Radiother Oncol 2013; 107: 325-332.
Van Dyk S, Narayan K, Fisher R et al. Conformal brachytherapy planning for cervical cancer using transabdominal ultrasound. Int J Radiat Oncol Biol Phys 2009; 75: 64-70.
Narayan K, van Dyk S, Bernshaw D et al. Ultrasound guided conformal brachytherapy of cervix cancer: survival, patterns of failure, and late complications. J Gynecol Oncol 2014; 25: 206-213.
Schmid MP, Nesvacil N, Pötter R et al. Transrectal ultrasound for image-guided adaptive brachytherapy in cervix cancer – an alternative to MRI for target definition? Radiother Oncol 2016; 120: 467-472.
Lim K, Chan P, Dinniwell R et al. Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia. Int J Radiat Oncol Biol Phys 2008; 70: 126-133.
Ohara K, Tanaka YO, Oki A et al. Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy. Radiat Med 2008; 26: 526-532.
Van Dyk S, Kondalsamy-Chennakesavan S, Schneider M et al. Comparison of measurements of the uterus and cervix obtained by magnetic resonance and transabdominal ultrasound imaging to Identify the brachytherapy target in patients with cervix cancer. Int J Radiat Oncol Biol Phys 2014; 88: 860-865.
Petric P, Kirisits C. Potential role of TRAns Cervical Endosonography (TRACE) in brachytherapy of cervical cancer: proof of concept. J Contemp Brachytherapy 2016; 8: 215-220.
 
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