Abstract
3/2021
vol. 16
Letter to the Editor
Treatment of intractable pruritus in patients with cholestasis with molecular adsorbents recirculating system dialysis: a case series
- Department of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Gdansk, Poland
- Department of General, Endocrine, and Transplant Surgery, Medical University of Gdansk, Gdansk, Poland
- Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
Gastroenterology Rev 2021; 16 (3): 254–256
Online publish date: 2021/09/17
Pruritus commonly occurs in patients with cholestatic liver diseases. Pruritus that is refractory to pharmacological treatment may be an indication for liver transplantation [1–3]. Pathogenesis of hepatic pruritus is still not fully understood. However, it is probably associated with the accumulation of pruritogens in plasma and other tissues as a result of cholestasis [4] (bile salts, bile acids, progesterone metabolites, lysophosphatidic acid, endogenous opioids [1]).
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