eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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3/2021
vol. 16
 
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abstract:
Letter to the Editor

Treatment of intractable pruritus in patients with cholestasis with molecular adsorbents recirculating system dialysis: a case series

Magdalena Antoszewska
1
,
Piotr Spychalski
2
,
Gerda Elisabeth Villadsen
3
,
Niels Kristian Muff Aagaard
3

1.
Department of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Gdansk, Poland
2.
Department of General, Endocrine, and Transplant Surgery, Medical University of Gdansk, Gdansk, Poland
3.
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
Gastroenterology Rev 2021; 16 (3): 254–256
DOI: https://doi.org/10.5114/pg.2021.108992
Online publish date: 2021/09/17
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Pruritus commonly occurs in patients with cholestatic liver diseases. Pruritus that is refractory to pharmacological treatment may be an indication for liver transplantation [1–3]. Pathogenesis of hepatic pruritus is still not fully understood. However, it is probably associated with the accumulation of pruritogens in plasma and other tissues as a result of cholestasis [4] (bile salts, bile acids, progesterone metabolites, lysophosphatidic acid, endogenous opioids [1]).
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