Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report

Małgorzata Sankowska; Ewelina Biało-Wójcicka; Karolina Rutkowska

doi:10.5114/dr.2025.154375

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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vol. 112

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Opis przypadku

Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report

Małgorzata Sankowska

^{1, 2}

,

Ewelina Biało-Wójcicka

^{1, 2}

,

Karolina Rutkowska

^{1, 2}

Dermatology Department for Adults, Międzylesie Tertiary Hospital, Warsaw, Poland
Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, Warsaw, Poland

Dermatol Rev/Przegl Dermatol 2025, 112, 199-204

DOI: https://doi.org/10.5114/dr.2025.154375

Data publikacji online: 2025/08/30

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AMA

Sankowska M, Biało-Wójcicka E, Rutkowska K. Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report. Dermatology Review/Przegląd Dermatologiczny. 2025;112(3):199-204. doi:10.5114/dr.2025.154375.

APA

Sankowska, M., Biało-Wójcicka, E.,  & Rutkowska, K. (2025). Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report. Dermatology Review/Przegląd Dermatologiczny, 112(3), 199-204. https://doi.org/10.5114/dr.2025.154375

Chicago

Sankowska, Małgorzata, Ewelina Biało-Wójcicka,  and Karolina Rutkowska. 2025. "Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report". Dermatology Review/Przegląd Dermatologiczny 112 (3): 199-204. doi:10.5114/dr.2025.154375.

Harvard

Sankowska, M., Biało-Wójcicka, E.,  and Rutkowska, K. (2025). Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report. Dermatology Review/Przegląd Dermatologiczny, 112(3), pp.199-204. https://doi.org/10.5114/dr.2025.154375

MLA

Sankowska, Małgorzata et al. "Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report." Dermatology Review/Przegląd Dermatologiczny, vol. 112, no. 3, 2025, pp. 199-204. doi:10.5114/dr.2025.154375.

Vancouver

Sankowska M, Biało-Wójcicka E, Rutkowska K. Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report. Dermatology Review/Przegląd Dermatologiczny. 2025;112(3):199-204. doi:10.5114/dr.2025.154375.

Metryki PlumX:

Introduction
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is an uncommon yet potentially fatal hypersensitivity reaction triggered by specific medications. A typical clinical presentation consists of maculopapular skin lesions, eosinophilia, fever and internal organ involvement.

Case report
This report highlights 2 cases of the DRESS syndrome caused by antiepileptic drug – lamotrigine and antibiotic – azithromycin. The first case involves an 18-year-old who developed widespread maculopapular rash, fever, lymphadenopathy, and elevated liver enzymes 3 weeks after initiating lamotrigine. The second case describes a 53-year-old female with severe rash covering 90% of her body, eosinophilia, and liver enzyme abnormalities shortly after azithromycin administration. Immediate discontinuation of the drug, combined with topical and systemic corticosteroids treatment led to the desired outcomes in both cases.

Conclusions
These cases underscore the critical importance of early diagnosis and management of DRESS, particularly when prescribing commonly used medications such as antiepileptic drugs and antibiotics.

słowa kluczowe:

DRESS syndrome, hypersensitivity reaction, lamotrigine, azithromycin

Indeks osobowy

Two Successfully Treated Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome): a Review of Literature and Case Report

Małgorzata Sankowska 1, 2 , Ewelina Biało-Wójcicka 1, 2 , Karolina Rutkowska 1, 2

DRESS syndrome, hypersensitivity reaction, lamotrigine, azithromycin

Małgorzata Sankowska

^{1, 2}

,

Ewelina Biało-Wójcicka

^{1, 2}

,

Karolina Rutkowska

^{1, 2}