zwyrodnieniowej stawów Usefulness of measurement of serum COMP and C2C level in end-stage osteoarthritis

Background: The aim of the study was to evaluate the level of COMP and C2C in serum end-stage osteoarthritis patients.
Material and methods: 17 end-stage osteoarthritis patients and 10 healthy persons were included in the study. Serum level COMP and C2C were measured by ELISA technique.
Results: COMP concentration in the serum end-stage osteoarthritis patients was statistically significantly lower than in the controls. C2C concentration in the serum end-stage osteoarthritis patients was not significantly lower than in the controls. Serum COMP and C2C level were not independent of age of osteoarthritis patients and healthy persons. The ROC curve for COMP suggests that serum concentration of this protein has medium usefulness for diagnosis of end-stage osteoarthritis. The ROC curve for C2C suggests that serum concentration of this biochemical marker has weak usefulness for diagnosis of end-stage osteoarthritis.
Conclusions: Low concentration of COMP and C2C in serum of osteoarthritis patients may suggest significant degradation of articular cartilage in end-stage osteoarthritis. Serum COMP and C2C levels seem not to be useful biochemical markers for laboratory diagnostics and assessment of progression in end-stage osteoarthritis.